Tuesday, August 21, 2012

A tribute to Dr. Ralph T. Holman

It is with great sadness we announce that Dr. Ralph T. Holman, AOCS Past President and renowned scientist has passed away at the age of 94.  AOCS extends condolences to Dr. Holman’s family and to his many friends.  AOCS Governing Board member and longtime friend, Dr. Douglas Bibus sent us the following message.

Dear Friends and Colleagues,

Dr Ralph Holman passed away peacefully yesterday morning surrounded by loved ones.  Ralph was an amazing scientist and an incredible person.

I was incredibly blessed by this man and enjoyed every opportunity to spend time with him.  He taught me science but even more importantly how to be a person.

Even in his age, he managed to continue to smile, maintain his optimism and keep all around entertained with his quick whit.  Ralph remained physically healthy until the end, requiring only a small dose of bp meds.  He passed away from complications related to pneumonia.   Ralph had one of the highest omega 3 levels that we have ever measured, likely due to his daily intake of sardines, fish and vegetables.

Ralph made many friends in the past few years in the nursing home.  He liked to sit with women at the lunch table because they were better conversationalists!  We had a dehydration event in January and the attending MD said Ralph would not leave the hospital.  One week later he was walking, joking, talking and reading scripture.  So many asked how could this be!

We had an amazing 94th birthday in March.  Ralph continued to say, what a nice surprise.  Ralph was known to walk and wheel the nursing home halls making sure everyone was ok and visiting with nurses and staff.

I have attached a copy of Ralph's obituary, his picture, a writeup by author Susan Allport, his essay entitled 'FINALE' that he wanted shared at his death.  Ralph was often frustrated in the 80s and 90s that omega 3 was not more widely accepted.  His paper to that effect is also attached.

A special thanks to Lola Cottew who has cared for Dr Holman daily for the past 7 years.  Lola's friendship and "gift of gab" dramatically provided quality of life to Ralph who while appearing quiet, loved to chat and visit.  A frequent sign on his back door said, " I am sleeping because I have no one to talk to, KNOCK HARD to wake me so we can visit!"

Additionally, Angie Hjelle, executive director of the Bethel University Foundation, made sure Ralph's affairs were handled professionally and carefully.  Her frequent trips to Austin/Albert Lea were welcomed by all of us and especially by Ralph who frequently asked where the pretty Bethel lady was.  Ralph often referred to us as his omega kids.  Our unique experiences with Ralph have cemented life long friendships.

May we all live with the spirit and love that Dr Holman gave every day.  Thank you to if you interacted with Dr Holman and/or continue to advance the science of omega 3/nutrition and the spirit of humanity.

Kind regards
Doug

Memorials are directed to Save the Children (www.savethechildren.org) who promote nutrition and health for disadvantaged children around the world or your preferred charity.
--

Obituary ~Dr. Ralph T. Holman 

Dr. Ralph T. Holman, 94 of Austin, MN, died peacefully surrounded by loved ones on Wednesday, August 15, 2012 at Mayo Clinic Health Systems, Albert Lea.

Ralph Theodore Holman was born March 4, 1918 in Minneapolis, MN the son of Alfred T. and May (Nilson) Holman. He was a graduate of Roosevelt High School, from Bethel College, The University of Minnesota and Rutgers University.

Ralph married Karla Calais on March 26, 1943 at the University of Minnesota Chapel. They lived in Minneapolis prior to moving to Sweden. Upon returning to the United States, they lived in Texas until moving to Austin, MN in 1951.

In 1946, Dr. Holman worked at the Karolinska Institute in Stockholm, Sweden with several Nobel Prize winners, including Sune Berstrom. He was the first person in the world to crystalize lipoxygenase, a significant enzyme in the inflammatory process. Following his time in Sweden, Dr. Holman spent time as a professor at Texas A and M University. In 1951, while a professor at the University of Minnesota in Minneapolis, Dr. Holman was invited to join the Hormel Institute in Austin MN which at the time was pioneering food stabilization technology. Dr. Holman spent the entirety of his career at his beloved Hormel Institute, University of Minnesota, finally retiring in 2001.

Professor Holman was a pioneer in the area of essential fatty acid research and nutrition, making several fundamental discoveries about the metabolism of fatty acids. He is perhaps best known for coining the term "Omega 3" in 1963 which Holman said came from his knowledge of the Bible and Sunday school from the passage "I am the Alpha and the Omega".  Dr. Holman was a devout Christian and led his life in pursuit of goodness and helping others.

Dr. Holman is regarded as the Father of Omega 3 fatty acids, discovering their essential nature, their metabolism and competition with omega 6 fatty acids and spawning many of the top lipid researchers in the day that passed through his lab at the Hormel Institute.  His science, discoveries, life and ambitions have improved the lives of millions around the globe through nutrition.

Dr. Holman was the Director of the Hormel Institute from 1975 to 1985 and on the Board of Directors for Hormel Foods.  He was a past president of the American Oil Chemists Society, and received numerous awards and honors including the Borden Award and the prestigious Baldwin Award. He was a member of the prestigious National Academy of Sciences, an invitation-only membership, the Royal Orchid Society, and many other scientific organizations.

His hobbies included photography and growing numerous orchids in a greenhouse he had constructed on the back of his home.  Dr. Holman also enjoyed spending time at his Swedish style cabin in Upsala Minnesota that he built with Karla and young son Ted. 

Dr. Holman was preceded in death by his parents and his loving wife, Karla.
Ralph is survived by his son Nils (Ted) Holman, Minneapolis, MN; nieces, nephews and cousins.


Publications of Ralph T. Holman
Updated 22oct96            

  1.       Ralph T. Holman, M. Wight Taylor and Walter C. Russell.  The Sulfur Balance of the Non-Laying, Molting and Laying Hen.  J. Nutr. 29, 277-281 (1945). (Master's Thesis).

  2.       Ralph T. Holman, Walter O. Lundberg, Walter M. Lauer and George O. Burr.  Spectrophotometric Studies of the Oxidation of Fats.  I.  Oleic Acid, Ethyl Oleate and Elaidic Acid.  J. Am. Chem. Soc. 67, 1285-1292 (1945) (Ph.D. Thesis).

  3.       Ralph T. Holman, Walter O. Lundberg and George O. Burr.  Spectrophotometric Studies of the Oxidation of Fats.  II. The Oxidation of Dienoic Fatty Acids.  J. Am. Chem. Soc. 67, 1386-1390 (1945).  (Ph.D. Thesis).

  4.       Ralph T. Holman, Walter O. Lundberg and George O. Burr.  Spectrophotometric Studies of the Oxidation of Fats.  III.  Ultraviolet Absorption Spectra of Oxidized Octadecatrienoic Acids.  J. Am. Chem. Soc. 67, 1390-1394 (1945).  (Ph.D. Thesis).

  5.       Ralph T. Holman and George O. Burr.  Spectrophotometric Studies of Fats. IV. Ultraviolet Absorption Spectra of Lipoxidase-Oxidized Fats.  Arch. Biochem. 37, 47-54 (1945).

  6.       Ralph T. Holman, Walter O. Lundberg and George O. Burr.  Spectrophotometric Studies of the Oxidation of Fats.  V.  The Color of Oxidized Fats in Alcoholic Alkali.  J. Am. Chem. Soc. 67, 1669-1672 (1945).

  7.       Ralph T. Holman and George O. Burr.  Spectrophotometric Studies of the Oxidation of Fats.  VI.  Oxygen Absorption and Chromophore Production in Fatty Esters.  J. Am. Chem. Soc. 68, 562-566 (1946).

  8.       Ralph T. Holman.  Spectrophotometric Studies of the Oxidation of Fats.  VII.  Oxygen Absorption and Chromophore Production in Lipoxidase-Oxidized Fatty  Esters.  Arch. Biochem. 10, 519-529 (1946).

  9.       Ralph T. Holman.  Spectrophotometric Studies of the Oxidation of Fats.  VIII. Coupled Oxidation of Carotene.  Arch. Biochem. 21, 51-57 (1949).

  10.     Ralph T. Holman.  Spectrophotometric Studies of the Oxidation of Fats.  IX. Coupled Oxidation of Vitamin A Acetate.  Arch. Biochem. 26, 85-91 (1950).
    
  11.     W. O. Lundberg, R. T. Holman and G. O. Burr.  Spectroscopic Changes in Fats During Rancidification.  Oil & Soap 23, 10-14 (1946).

 12.      W. O. Lundberg, R. T. Holman and G. O. Burr.  Deterioration of Fats and Oils. Quartermaster Corps Manual 17-7, p. 27 (1945).

 13.      Irving I. Rusoff, Ralph T. Holman and George O. Burr.  A Table of Spectroscopic Data on Fats, Fatty Acids, and Their Esters.  Oil & Soap 22, 290-294 (1945).

 14.      Norman Kretchmer, Ralph T. Holman and George O. Burr.  A Submicro Method for the Determination of Iodine Number of Lipids.  Arch. Biochem. 10, 101-105 (1946).

 15.      Otto C. Elmer and Ralph T. Holman.  Preparation of Linoleic and Linolenic Acid Esters of Several Poly-Hydroxy Alcohols.  Off. Dig., Fed. Paint Varn. Prod. Clubs 263, 711-716 (1946).

 16.      Ralph T. Holman and Otto C. Elmer.  The Rates of Oxidation of Unsaturated Fatty Acids and Esters.  J. Am. Oil Chem. Soc. 24, 127-129 (1947).

 17.      Hugo Theorell, Ralph T. Holman and Ake Akeson.  A Note on the Preparation of Crystalline Soy Bean Lipoxidase.  Arch. Biochem. 14, 250-252 (1947).

 18.      Hugo Theorell, Ralph T. Holman and Ake Akeson.  Crystalline Lipoxidase. Acta Chem. Scand. 1, 571-576 (1947).

 19.      Ralph Theodore Holman.  Crystalline Lipoxidase.  II.  Lipoxidase Activity. Arch. Biochem. 15, 403-413 (1947).

 20.      Ralph T. Holman, Frances Panzer, B. S. Schweigert and Stanley R. Ames. Crystalline Lipoxidase.  III.  Amino Acid Composition.  Arch. Biochem. 26, 199-204 (1950).

 21.      Ralph T. Holman and George O. Burr.  Alkali Conjugation of the Unsaturated Fatty Acids.  Arch. Biochem. 19, 474-482 (1948).

 21a.    Irma Rieckehoff, Ralph Holman and George Burr.  Effect of Diet on Polyethenoid Fatty Acids of Rat Tissues.  Fed. Proc. 6, No. 1, Mar. (1947).  (Abstract)

 22.      Irma G. Rieckehoff, Ralph T. Holman and G. O. Burr.  Polyethenoid Fatty Acid Metabolism.  Effect of Dietary Fat on Polyethenoid Fatty Acids of Rat Tissues.  Arch. Biochem. 20, 331-340 (1949).

 23.      Carl Widmer, Jr. and Ralph T. Holman.  Polyethenoid Fatty Acid Metabolism. II.  Deposition of Polyunsaturated Fatty Acids in Fat-Deficient Rats Upon Single Fatty Acid Supplementation.  Arch. Biochem. 25, 1-12 (1950).

 24.      Ralph T. Holman and Thomas S. Taylor.  Polyethenoid Fatty Acid Metabolism. III. Arachidonate Supplementation.  Arch. Biochem. 29, 295-301 (1950).

 25.      Patrick W. Witten and Ralph T. Holman.  Polyethenoid Fatty Acid Metabolism.  V. Prooxidant-Antioxidant Effect.  Arch. Biochem. Biophys. 37, 90-98 (1952).

 26.      Patrick W. Witten and Ralph T. Holman.  Polyethenoid Fatty Acid Metabolism. VI. Effect of Pyridoxine on Essential Fatty Acid Conversions.  Arch. Biochem. Biophys. 41, 266-273 (1952).

 27.      Ralph T. Holman and Sheldon I. Greenberg.  Polyethenoid Fatty Acid Metabolism.  VII.  Effect of Oxidized Linoleate Preparations.  Arch. Biochem. Biophys. 49, 49-57 (1954).

 28.      O. S. Privett, F. J. Pusch and Ralph T. Holman.  Polyethenoid Fatty Acid Metabolism.  VIII.  Nonpotency of cis-9,trans-12-Linoleate as Essential Fatty Acid.  Arch. Biochem. Biophys. 57, 156-162 (1955).

 29.      Sune Bergstrom and Ralph T. Holman.  Total Conjugation of Linoleic Acid in Oxidation with Lipoxidase.  Nature 161, 55-56 (1948).

 30.      Sune Bergstrom and Ralph T. Holman.  Lipoxidase and the Autoxidation of Unsaturated Fatty Acids.  Adv. Enzymol. 8, 425-457 (1948).

 31.      Ralph Theodore Holman.  Lipoxidase Activity and Fat Composition of Germinating Soy Beans.  Arch. Biochem. 17, 459-466 (1948).

 32.      V. Lorraine Schneider, Ralph T. Holman and George O. Burr.  A Monolayer Study of the Isomerism of Unsaturated and Oxy Fatty Acids.  J. Phys. Colloid Chem. 53, 1016-1029 (1949).

 33.      Ralph T. Holman.  Mechanism of Action of Lipoxidase.  Transactions of the Third Conference on Biological Antioxidants, Josiah Macy Jr. Foundation, p. 131 (1948).

 34.      Ralph T. Holman.  Spectrophotometric Studies of the Oxidation of Linoleates.  Transactions of the First Conference on Biological Antioxidants, Josiah Macy Jr. Foundation, pp. 37-41 (1946).

 35.      Ralph T. Holman and Lennart Hagdahl.  Displacement Analysis of Lipides. Preliminary Studies with Normal Saturated Fatty Acids.  Arch. Biochem 17, 301-310 (1948).

 36.      Lennart Hagdahl and Ralph T. Holman.  Displacement Analysis of Lipids.  II. Increased Separability of Fatty Acids by Depressed Solubility.  J. Am. Chem.  Soc. 72, 701-705 (1950).

 37.      Ralph T. Holman and Lennart Hagdahl.  Displacement Analysis of Lipides.  III.  Separation of Normal Saturated Fatty Acids from Formic to Behenic.  J. Biol. Chem. 182, 421-427 (1950).

 38.      Ralph T. Holman.  Displacement Analysis of Lipids.  IV.  Carrier Displacement Separation of Saturated Fatty Acids.  J. Am. Chem. Soc. 73, 1261-1263 (1951).

 39.      Ralph T. Holman.  Displacement Analysis of Lipids.  V.  Separation of Substances Analogous to Fatty Acids.  J. Am. Chem. Soc. 73, 3337-3340 (1951).

 40.      Ralph T. Holman and William T. Williams.  Displacement Analysis of Lipids.  VI. Separation of Unsaturated Acids.  J. Am. Chem. Soc. 73, 5285-5289 (1951).

 41.      Ralph T. Holman.  Displacement Analysis of Lipids.  VII.  Carrier Separation of Unsaturated Fatty Acids.  J. Am. Chem. Soc. 73, 5289-5292 (1951).

 42.      James G. Hamilton, Jr. and Ralph T. Holman.  Displacement Analysis of Lipides. VIII.  Preliminary Studies with Steroids.  Arch. Biochem. Biophys. 36, 456-461 (1952).

 43.      N. A. Khan, W. O. Lundberg and Ralph T. Holman.  Displacement Analysis of Lipids.  IX.  Products of the Oxidation of Methyl Linoleate.  J. Am. Chem. Soc. 76, 1779-1784 (1954).

 44.      James G. Hamilton and Ralph T. Holman.  Displacement Analysis of Lipids.  X. Model Mixtures of Glycerides.  J. Am. Chem. Soc. 76, 4107-4109 (1954).

 45.      Ralph T. Holman.  Crossing Over. A New Technique in Displacement Analysis with the Tiselius-Claesson Interferometer.  Anal. Chem. 22, 832-833 (1950).

 46.      Ralph T. Holman and Lennart Hagdahl.  Tiselius-Claesson Interferometric Adsorption Analysis Apparatus. Improvements in Design and Use.  Anal. Chem. 23, 794-797 (1951).

 47.      Ralph T. Holman and Sune Bergstrom.  Lipoxidase or Unsaturated-Fat Oxidase. In "The Enzymes," Vol. II, Chapter 60, Eds. J. B. Sumner and K. Myrback,  Academic Press, New York, pp. 559-580 (1951).

 48.      Pao-Tung Huang, Ralph T. Holman and William M. Potts.  Spectrophotometric and Chromatographic Investigations of the Oil of Sapium sebiferum.  J. Am. Oil Chem. Soc. 26, 405-407 (1949).

 49.      Leah Cohadas Berk, Norman Kretchmer, Ralph T. Holman and George O. Burr. Microdetermination of Unsaturated Fatty Acids by Alkali Isomerization. Anal. Chem. 22, 718-720 (1950).

 50.      Herman Schlenk and Ralph T. Holman.  Separation and Stabilization of Fatty Acids by Urea Complexes.  J. Am. Chem. Soc. 72, 5001-5004 (1950).

 51.      Hermann Schlenk and Ralph T. Holman.  The Urea Complexes of Unsaturated Fatty Acids.  Science 112, 19-20 (1950).

 52.      Ralph T. Holman.  Metabolism of Isomers of Linoleic and Linolenic Acids (18399).  Proc. Soc. Exp. Biol. Med. 76, 100-102 (1951).

 53.      Ralph T. Holman.  Fatty Acids in Nutrition.  Proc. Third Conference on Research, Am. Meat Inst., pp. 1-10 (1951).

 54.      Ralph T. Holman.  Die Rolle der Fettsauren in der Ernahrung.  Fette Seifen 53, 332-336 (1951).

 55.      Ralph T. Holman and Nils Andreas Sorensen.  Spectral and Oxidation Studies on Matricaria Ester (n-Decadiene-2,8-diyne-4,6-oic Acid Methyl Ester).  Acta  Chem. Scand. 4, 416-421 (1950).

 56.      Ralph T. Holman.  Chromatography of Fatty Acids and Related Substances.  Prog. Chem. Fats Other Lipids 1, 104-126 (1952).

 57.      Robert S. Harris and Ralph T. Holman.  Essential Fatty Acids.  In "The Vitamins," Vol. II, Eds. Sebrell and Harris, Academic Press, New York,  Chapter 7, pp. 267-319 (1954).

 58.      Ralph T. Holman.  Autoxidation of Fats and Related Substances.  Prog. Chem. Fats Other Lipids 2, 51-98 (1954).

 59.      Ralph T. Holman.  Mode of Action of Lipoxidase.  Trans. Am. Assoc. Cereal Chem. 11, 135-146 (1953).

 60.      Ralph T. Holman and Sheldon I. Greenberg.  Highly Unsaturated Fatty Acids.  I. A Survey of Possible Animal Sources.  J. Am. Oil Chem. Soc. 30, 600-601  (1953).

 61.      Ahmed M. Abu-Nasr, William M. Potts and Ralph T. Holman.  Highly Unsaturated Fatty Acids.  II.  Fractionation by Urea Inclusion Compounds.  J. Am. Oil Chem. Soc. 31, 16-20 (1954).

 62.      Ahmed M. Abu-Nasr and Ralph T. Holman.  Highly Unsaturated Fatty Acids.  III. Isolation of Methyl Eicosapentaenoate, Ethyl Docosapentaenoate, and Ethyl Docosahexaenoate from Cod Liver Oil Esters by Chromatography.  J. Am. Oil Chem. Soc. 31, 41-45 (1954).

 63.      Hilda F. Wiese, Ralph T. Holman and Arild E. Hansen.  Spectrographic Evidence of Deficiency of Unsaturated Fatty Acids in Serum and Tissues of Dogs on a Low Fat Diet.  Fed. Proc. 9, 374 (1950).  (Abstract)

 64.      Hermann Schlenk and Ralph T. Holman.  Methanolysis of Triglycerides by an Anion Exchange Resin.  J. Am. Oil Chem. Soc. 30, 103-104 (1953).

 65.      Ralph T. Holman.  Nutritional Value of Fat.  Cherry-Burrill Circle, March-April, pp. 11-13, 24 (1954).

 66.      Ralph T. Holman.  The Nutritive Values of Fats.  Milk Plant Monthly, March, pp. 33-34, 42 (1954).

 66a.    Annual Report of The Hormel Institute, 1951-52.
   
 66b.    Annual Report of The Hormel Institute, 1952-53.

 66c.    Eldon G. Hill, Ralph T. Holman and W. O. Caster.  Requirement of Swine for Dietary Linoleate.  Fed. Proc. 20, No. 1, Part I, March (1961).  (Abstract)

 66d.    Annual Report of The Hormel Institute, 1953-54.

 66e.    Annual Report of The Hormel Institute, 1954-55.

 66f.     Annual Report of The Hormel Institute, 1955-56.

 67.      Ralph T. Holman and Siret Ener.  Use of Urea-Inclusion Compound Containing Essential Fatty Acid in an Experimental Diet.  J. Nutr. 53, 461-468 (1954).

 68.      Ralph T. Holman.  Removing Charcoal from the Skin.  Chemist-Analyst 43, 80 (1954).

 69.      Ralph T. Holman.  Measurement of Lipoxidase Activity.  In "Methods of Biochemical Analysis,"  Ed. D. Glick, Interscience Publ., New York, pp. 113-119 (1955).

 70.      Ralph T. Holman and D. P. Hanks.  Isolation of 2,4-Dodecadienoic Acid from the Seed Oil of Sebestiana lingustrina.  J. Am. Oil Chem. Soc. 32, 356-357 (1955).

 71.      Ralph T. Holman.  The Nutritional Significance of Essential Fatty Acids.  Food Nutr. News 26, 1 and 4 (1955).

 72.      Ahmed M. Abu-Nasr and Ralph T. Holman.  Isomerization of Polyunsaturated Fatty Acids and Their Esters by Sodium Amide in Liquid Ammonia.  J. Am. Oil Chem. Soc. 32, 414-418 (1955).

 73.      J. J. Peifer and Ralph T. Holman.  Essential Fatty Acids, Diabetes, and Cholesterol.  Arch. Biochem. Biophys. 57, 520-521 (1955).

 74.      Ralph T. Holman.  Function and Metabolism of Essential Fatty Acids.  In "Biochemical Problems of Lipids."  Proceedings of the Second International Conference, University of Ghent, Eds. G. Popjak and E. Le Breton, July 1955, Butterworths Scientific Publications, London, pp. 463-471 (1956).

 75.      Ralph T. Holman.  The Function of Essential Fatty Acids.  Sven. Kem. Tidskr. 68, 282-290 (1956).

 76.      Ralph T. Holman.  Measurement of Polyunsaturated Fatty Acids.  In "Methods of Biochemical Analysis," Vol. IV, Ed. D. Glick, Interscience Publ., New York, pp. 99-138 (1957).

 77.      Ralph T. Holman and Page R. Edmondson.  Near-Infrared Spectra of Fatty Acids and Some Related Substances.  Anal. Chem. 28, 1533-1538 (1956).

 78.      Editors (Holman, Lundberg and Malkin):  Progress in the Chemistry of Fats and Other Lipids, Pergamon Press, London, Vol. I, 186 pages, 1952.

 79.      Editors (Holman, Lundberg and Malkin):  Progress in the Chemistry of Fats and Other Lipids, Pergamon Press, London, Vol. II, 347 pages, 1954.

 80.      Editors (Holman, Lundberg and Malkin):  Progress in the Chemistry of Fats and Other Lipids, Pergamon Press, London, Vol. III, 475 pages, 1955.

 81.      Ralph T. Holman and Erik Aaes-Jorgensen.  Effects of trans Fatty Acid Isomers upon Essential Fatty Acid Deficiency in Rats.  Proc. Soc. Exp. Biol. Med. 93, 175-179 (1956).

 82.      S. Kuramoto, J. J. Jezeski and R. T. Holman.  Displacement Separation of Some of the Component Fatty Acids of Milk Fat.  J. Dairy Sci. 40, 314-322 (1957).

 83.      W. Montag, E. Klenk, H. Hayes and R. T. Holman.  The Eicosapolyenoic Acids Occurring in the Glycerophosphatides of Beef Liver.  J. Biol. Chem. 227, 53-60 (1957).

 84.      Ralph T. Holman.  The Lipids in Relation to Atherosclerosis.  Am. J. Clin. Nutr. 8, 95-103 (1960).

 85.      Ralph T. Holman, Herbert Hayes, Haqvin Malmros and Gerhard Wigand.  Effects of Dietary Fat upon Plasma Polyunsaturated Acids.  Proc. Soc. Exp. Biol. Med. 96, 705-709 (1957).

 86.      Ralph T. Holman.  Essential Fatty Acids.  Nutr. Rev. 16, 33-35 (1958).

 87.      Ralph T. Holman, Herbert Hayes and Page R. Edmondson.  Analysis of Unsaturated Fatty Acids.  In "Essential Fatty Acids," Proc. Fourth International Conf. on  Biochem. Prob. of Lipids, Oxford, July 15-18, 1957, Butterworths Scientific Publications, pp. 9-15 (1958).

 88.      Ralph T. Holman and Herbert Hayes.  Determination of Polyunsaturated Acids in Lipides of Plasma and Tissue.  Anal. Chem. 30, 1422-1425 (1958).

 89.      Eldon G. Hill, Egis L. Warmanen, Herbert Hayes and Ralph T. Holman.  Effects of Essential Fatty Acid Deficiency in Young Swine (23192).  Proc. Soc. Exp. Biol. Med. 95, 274-278 (1957).

 90.      Ralph T. Holman, Siret Ener and Page R. Edmondson.  Detection and Measurement of cis Unsaturation in Fatty Acids.  Arch. Biochem. Biophys. 80, 72-79 (1959).

 91.      Erik Aaes-Jorgensen and Ralph T. Holman.  Essential Fatty Acid Deficiency.  I.  Content of Polyenoic Acids in Testes and Heart as an Indicator of EFA Status.  J. Nutr. 65, 633-641 (1958).

 92.      Erik Aaes-Jorgensen, E. E. Leppik, H. W. Hayes and Ralph T. Holman.  Essential Fatty Acid Deficiency.  II.  In Adult Rats.  J. Nutr. 66, 245-259 (1958).

 93.      Ralph T. Holman.  The Separation of Fatty Acids.  Experientia 14, 121-127  (1958).

 94.      Ralph T. Holman, Christense Nickell, Orville S. Privett and Page R. Edmondson.  Detection and Measurement of Hydroperoxides by Near Infrared Spectrophotometry.  J. Am. Oil Chem. Soc. 35, 422-425 (1958).

 95.      Ralph T. Holman and Sheldon I. Greenberg.  A Note on the Toxicities of Methyl Oleate Peroxide and Ethyl Linoleate Peroxide.  J. Am. Oil Chem. Soc. 35, 707 (1958).

 96.      H. K. Mangold, H. Hayes and R. T. Holman.  Estudios sobre los eteres de glicerilo y los aldehidos grasos.  Grasas Aceites (Seville) 10, 148-149 (1959).

 97.      R. T. Holman.  Purity of Compounds.  In "Essential Fatty Acids," Ed. H. M. Sinclair, Academic Press, New York, and Butterworth, London, pp. 238-241 (1958).

 98.      R. T. Holman and E. Aaes-Jorgensen.  Relationships Between Polyunsaturated Fatty Acids and Circulating Cholesterol.  In "Essential Fatty Acids," Ed. H. M. Sinclair, Butterworths Scientific Publications, London, pp. 156-157 (1958).

 99.      Erik Aaes-Jorgensen, Orville S. Privett and Ralph T. Holman.  Essential Fatty Acid Activities of Hydrocarbons and Alcohols Analogous to Linoleate and Linolenate.  J. Nutr. 67, 413-421 (1959).

100.     Orville S. Privett, Erik Aaes-Jorgensen, Ralph T. Holman and Walter O.Lundberg.  The Effect of Concentrates of Polyunsaturated Acids from Tuna Oil upon Essential Fatty Acid Deficiency.  J. Nutr. 67, 423-432 (1959).

101.     James J. Peifer and Ralph T. Holman.  Effect of Saturated Fat upon Essential Fatty Acid Metabolism of the Rat.  J. Nutr. 68, 155-168 (1959).
102.     Ralph T. Holman and Carl Widmer.  Polyunsaturated Fatty Acids in Beef Heart  Mitochondria and Derived Enzymically Active Lipoprotein Fractions.  J. Biol. Chem. 234, 2269-2271 (1959).

103.     Ralph T. Holman.  Essential Fatty Acids in Nutrition and Metabolism.  A.M.A. Arch. Int. Med. 105, 33-38 (1960).

104.     Ralph T. Holman.  Food Composition and Method of Preserving Same.  U. S. Patent 2,875,000 (1959).

105.     Warren J. Warwick, Ralph T. Holman, Paul G. Quie and Robert A. Good.  Chylous Ascites and Lymphedema.  AMA Am. J. Dis. Child. 98, 317-329 (1959).

106.     Ralph T. Holman.  The Ratio of Trienoic:Tetraenoic Acids in Tissue Lipids as a Measure of Essential Fatty Acid Requirement.  J. Nutr. 70, 405-410 (1960).

107.     Ralph T. Holman and James J. Peifer.  Acceleration of Essential Fatty Acid Deficiency by Dietary Cholesterol.  J. Nutr. 70, 411-417 (1960).

108.     Ralph T. Holman.  The Lipids in Relation to Atherosclerosis.  Am. J. Clin. Nutr. 8, 95-103 (1960).

109.     Hermann Schlenk, H. K. Mangold, J. L. Gellerman, W. E. Link, R. A. Morrissette, R. T. Holman and H. Hayes.  Comparative Analytical Studies of Fatty Acids of the Alga Chlorella pyrenoidosa.  J. Am. Oil Chem. Soc. 37, 547-552 (1960).

110.     O. S. Privett, F. J. Pusch, R. T. Holman and W. O. Lundberg.  Essential Fatty Acid Properties of Tuna, Herring and Menhaden Oils.  J. Nutr. 71, 66-69 (1960).

111.     Ralph T. Holman.  Factors Influencing the Requirement for Polyunsaturated Fatty Acids.  Am. J. Clin. Nutr. 8, 403-410 (1960).

112.     E. Aaes-Jorgensen, O. S. Privett and R. T. Holman.  Essential Fatty Acid Deficiency in Rats.  In "Biochemistry of Lipids," Pergamon Press, Oxford, pp. 136-142 (1960).

113.     Ralph T. Holman.  Enzymes and Polyunsaturated Fatty Acids.  In "Food Enzymes," Chapter 6, Ed. H. W. Schultz, AVI Publishing Co., Westport, CT, pp. 75-83 (1960).

114.     Ralph T. Holman.  Behovet av essentiella fettsyror.  (Requirement of Essential Fatty Acids), in Swedish.  Naringsforshning, pp. 56-58 (1960).

115.     Lindsay J. Morris, Ralph T. Holman and Krister Fontell.  Alteration of Some Long-Chain Esters During Gas-Liquid Chromatography.  J. Lipid Res. 1, 412-420 (1960).

116.     Krister Fontell, Ralph T. Holman and Georg Lambertsen.  Some New Methods for Separation and Analysis of Fatty Acids and Other Lipids.  J. Lipid Res. 1, 391-404 (1960).

117.     John A. Williams, Akhila Sharma, Lindsay J. Morris and Ralph T. Holman.  Fatty Acid Composition of Feces and Fecaliths (26052).  Proc. Soc. Exp. Biol. Med. 105, 192-195 (1960).

118.     L. J. Morris, R. T. Holman and K. Fontell.  Vicinally Unsaturated Hydroxy Acids in Seed Oils.  J. Am. Oil Chem. Soc. 37, 323-327 (1960).

119.     W. O. Caster and Ralph T. Holman.  Statistical Study of the Relationship Between Dietary Linoleate and the Fatty Acids of Heart and Blood Lipids. J. Nutr. 73, 337-346 (1961).

120.     Eldon G. Hill, E. L. Warmanen, C. L. Silbernick and Ralph T. Holman.  Essential Fatty Acid Nutrition in Swine.  I.  Linoleate Requirement Estimated from Triene:Tetraene Ratio of Tissue Lipids.  J. Nutr. 74, 335-341 (1961).

121.     Lindsay J. Morris, Ralph T. Holman and Krister Fontell.  Naturally Occurring Epoxy Acids:  I.  Detection and Evaluation of Epoxy Fatty Acids by Paper, Thin-Layer, and Gas-Liquid Chromatography.  J. Lipid Res. 2, 68-76 (1961).

122.     Lindsay J. Morris and Ralph T. Holman.  Naturally Occurring Epoxy Acids:  II. Detection and Measurement of Long-Chain Epoxy Acids by Near Infrared Spectrophotometry.  J. Lipid Res. 2, 77-82 (1961).

123.     L. J. Morris, H. Hayes and R. T. Holman.  Naturally-Occurring Epoxy Acids.  III.  Methods for Their Isolation.  J. Am. Oil Chem. Soc. 38, 316-321 (1961).

124.     Eduardo Vioque and Ralph T. Holman.  p-Phenylazophenacyl Esters of Some Acids Derived from or Related to Lipides.  Anal. Chem. 33, 1444 (1961).

125.     E. Vioque, L. J. Morris and R. T. Holman.  Minor Components of Olive Oils.  II.  trans-9,10-Epoxystearic Acid in Orujo Oil.  J. Am. Oil Chem. Soc. 38, 489-492 (1961).

126.     Ralph T. Holman.  How Essential Are Fatty Acids?  J. Am. Med. Assoc. 178, 930-933 (1961).

127.     Leland K. Dahle and Ralph T. Holman.  Modified Iodometric Method for Semi-microdetermination of Lipide Peroxides.  Anal. Chem. 33, 1960-1961 (1961).

128.     E. Vioque and R. T. Holman.  Quantitative Estimation of Esters by Thin-Layer Chromatography.  J. Am. Oil Chem. Soc. 39, 63-66 (1962).

129.     R. T. Holman.  Essential Fatty Acid Requirement.  Int. Dairy Fed. 1962 Bull., Part II, pp. 1-6 (1962).

130.     Ralph T. Holman.  Some Modern Methods of Separation and Analysis Applicable to Fish Oils.  In "Fish in Nutrition," Eds. Eirik Heen and Rudolf Kreuzer, Fishing News (Books) Ltd., Ludgate House, London, pp. 117-124 (1962).

131.     Ara Chalvardjian, Lindsay J. Morris and Ralph T. Holman.  Effect of Dietary Epoxyoleic Acid Upon Rats.  J. Nutr. 76, 52-58 (1962).

132.     W. O. Caster, Philip Ahn, Eldon G. Hill, H. Mohrhauer and Ralph T. Holman.  Determination of Linoleate Requirement of Swine by a New Method of Estimating Nutritional Requirement.  J. Nutr. 78, 147-154 (1962).

133.     Ralph T. Holman.  Polyunsaturated Fats in Nutrition.  Proc. Fourteenth Res. Conf. Am. Meat Inst. Fdn., pp. 85-87 (1962).

134.     Leland K. Dahle, Eldon G. Hill and Ralph T. Holman.  The Thiobarbituric Acid Reaction and the Autoxidations of Polyunsaturated Fatty Acid Methyl Esters.  Arch. Biochem. Biophys. 98, 253-261 (1962).

134a.   Ralph T. Holman.  Djurorganismens behov av essentiella fettsyror.  Abstract #11 in Nordiska kemistmotet, Abo, Finland, 1962.

135.     E. Vioque and R. T. Holman.  Characterization of the Ketodienes Formed in the Oxidation of Linoleate by Lipoxidase.  Arch. Biochem. Biophys. 99, 522-528 (1962).

136.     Hans Mohrhauer and Ralph T. Holman.  The Effect of Dose Level of Essential Fatty Acids upon Fatty Acid Composition of the Rat Liver.  J. Lipid Res. 4, 151-159 (1963).

137.     Georg Lambertsen and Ralph T. Holman.  Partial Characterization of the Hydrocarbons of Herring Oil.  Acta Chem. Scand. 17, 281-282 (1963).

138.     W. O. Caster, Eldon G. Hill and Ralph T. Holman.  Estimation of Essential Fatty Acid Intake in Swine.  J. Anim. Sci. 22, 389-392 (1963).

139.     Hans Mohrhauer and Ralph T. Holman.  The Effect of Dietary Essential Fatty Acids upon Composition of Polyunsaturated Fatty Acids in Depot Fat and Erythrocytes of the Rat.  J. Lipid Res. 4, 346-350 (1963).

140.     Hans Mohrhauer and Ralph T. Holman.  Alteration of the Fatty Acid Composition of Brain Lipids by Varying Levels of Dietary Essential Fatty Acids. J. Neurochem. 10, 523-530 (1963).

141.     Ralph T. Holman and Hans Mohrhauer.  A Hypothesis Involving Competitive Inhibitions in the Metabolism of Polyunsaturated Fatty Acids.  Acta Chem. Scand. 17, S84-S90 (1963).

142.     Rene Maier and Ralph T. Holman.  Naturally Occurring Triglycerides Possessing Optical Activity in the Glycerol Moiety.  Biochemistry 3, 270-274 (1964).

143.     Editors (Holman, Lundberg and Malkin):  Progress in the Chemistry of Fats and Other Lipids.  Pergamon Press, London, Vol. IV, 289 pages, 1957.

144.     Editors (Holman, Lundberg and Malkin):  Progress in the Chemistry of Fats and Other Lipids.  Pergamon Press, London, Vol. V, 311 pages, 1958.

145.     Editors (Holman, Lundberg and Malkin):  Progress in the Chemistry of Fats and Other Lipids.  Pergamon Press, London, Vol. VI, 364 pages, 1963.

146.     Hans Mohrhauer and Ralph T. Holman.  Effects of Dietary Essential Fatty Acids upon Polyunsaturated Fatty Acids in Rat Heart Tissue.  Biochem. Probl. Lipids, B.B.A. Library 1, 446-452 (1963).

147.     Hans Mohrhauer and Ralph T. Holman.  Effect of Linolenic Acid Upon the Metabolism of Linoleic Acid.  J. Nutr. 81, 67-74 (1963).

148.     Ralph T. Holman.  Hiawatha's Meeting.  J. Am. Oil Chem. Soc. 40, 16, 46-47, 54 (1963).

149.     Joseph J. Rahm and Ralph T. Holman.  The Relationship of Single Dietary Polyunsaturated Fatty Acids to Fatty Acid Composition of Lipids from Subcellular Particles of Liver.  J. Lipid Res. 5, 169-176 (1964).

150.     Ralph T. Holman, W. O. Caster and Hilda F. Wiese.  The Essential Fatty Acid Requirement of Infants and the Assessment  of Their Dietary Intake of Linoleate by Serum Fatty Acid Analysis.  Am. J. Clin. Nutr. 14, 70-75 (1964).

151.     Ralph T. Holman, W. O. Caster and Hilda F. Wiese.  Estimation of Linoleate Intake of Men from Serum Lipid Analysis.  Am. J. Clin. Nutr. 14, 193-196 (1964).

152.     Joseph J. Rahm and Ralph T. Holman.  Effect of Linoleic Acid upon the Metabolism of Linolenic Acid.  J. Nutr. 84, 15-19 (1964).

153.     Joseph J. Rahm and Ralph T. Holman.  Studies of the Metabolism of Polyunsaturated Acids by Short-term Experiments.  J. Nutr. 84, 149-154 (1964).

154.     Ralph T. Holman.  Nutritional and Metabolic Interrelationships Between Fatty Acids.  Fed. Proc. 23, 1062-1067 (1964).

155.     Ralph T. Holman.  Some Studies in Essential Fatty Acid Metabolism and Nutrition.  In "Metabolism of Lipids as Related to Atherosclerosis,"  Ed. F. A. Kummerow, Thomas Publ., Springfield, IL, pp. 186-197 (1965).

156.     Ralph T. Holman and H. H. Hofstetter.  The Fatty Acid Composition of the Lipids from Bovine and Porcine Reproductive Tissues.  J. Am. Oil Chem. Soc. 42, 540-544 (1965).

157.     H. H. Hofstetter, N. Sen and R. T. Holman.  Characterization of Unsaturated Fatty Acids by Gas-Liquid Chromatography.  J. Am. Oil Chem. Soc. 42, 537-540 (1965).

158.     Zvi Selinger and Ralph T. Holman.  The Effects of trans,trans-Linoleate upon the Metabolism of Linoleate and Linolenate and the Positional Distribution of Linoleate Isomers in Liver Lecithin.  Biochim. Biophys. Acta 106, 56-62 (1965).

159.     Ralph T. Holman, H. W. Hayes, Aime Rinne and Lars Soderhjelm.  Polyunsaturated Fatty Acids in Serum of Infants Fed Breast Milk or Cow's Milk.  Acta Paediatr. Scand. 54, 573-577 (1965).

160.     Berndt E. Hagstrom and Ralph T. Holman.  The Effect of Free Fatty Acids upon the Fertilization of the Eggs of the Sea Urchin.  Protoplasma 60, 211-217 (1965).

161.     Hans Mohrhauer and Ralph T. Holman.  Tracer Experiments to Assess Metabolic Conversions of Polyunsaturated Fatty Acids.  J. Am. Oil Chem. Soc. 42, 639-643 (1965).

162.     Ralph T. Holman, Hans Mohrhauer, Eldon G. Hill and W. O. Caster.  Muscular Dystrophy:  A Problem in Polyunsaturated Fatty Acid Metabolism?  Am. J. Clin. Nutr. 16, 453 (1965).

163.     Jorge J. Casal and Ralph T. Holman.  The Effect of Kind of Dietary Carbohydrate upon the Composition of Liver Fatty Acids of the Rat.  J. Am. Oil Chem. Soc. 42, 1134-1137 (1965).

164.     Pilar Teresa Garcia and Ralph T. Holman.  Competitive Inhibitions in the Metabolism of Polyunsaturated Fatty Acids Studied via the Composition of Phospholipids, Triglycerides and Cholesteryl Esters of Rat Tissues.  J. Am. Oil Chem. Soc. 42, 1137-1141 (1965).

165.     W. O. Caster, Hans Mohrhauer and Ralph T. Holman.  Effects of Twelve Common Fatty Acids in the Diet upon the Composition of Liver Lipid in the Rat.  J. Nutr. 89, 217-225 (1966).

166.     Howard W. Sprecher, Rene Maier, M. Barber and Ralph T. Holman.  Structure of an Optically Active Allene-containing Tetraester Triglyceride Isolated from the Seed Oil of Sapium sebiferum.  Biochemistry 4, 1856-1863 (1965).



167.     Ralph T. Holman.  Metabolism of Polyunsaturated Acids.  In "Symposia of the Swedish Nutrition Foundation.  IV.  Polyunsaturated Fatty Acids as Nutrients," Eds. G. Blix, Almqvist and Wiksell, Stockholm, pp. 31-42 (1966).

168.     Ralph T. Holman.  General Introduction to Polyunsaturated Acids.  Prog. Chem. Fats Other Lipids 9, 3-12 (1966).

169.     Ralph T. Holman and Joseph J. Rahm.  Analysis and Characterization of Polyunsaturated Fatty Acids.  Prog. Chem. Fats Other Lipids 9, 13-90 (1966).

170.     W. W. Christie and R. T. Holman.  Mass Spectrometry of Lipids.  I.  Cyclopropane Fatty Acid Esters.  Lipids 1, 176-182 (1966).

171.     Ralph T. Holman, Manfred Deubig and Herbert Hayes.  Pyrolysis Chromatography of Lipids.  I.  Mass Spectrometric Identification of Pyrolysis Products of Hydrocarbons.  Lipids 1, 247-253 (1966).

172.     Balwant Ahluwalia and Ralph T. Holman.  Fatty Acid Distribution in the Bovine Pre- and Postpartum Testis.  Lipids 1, 197-201 (1966).

173.     R. T. Holman.  Special AOCS Award Highlights Symposium Honoring George Burr.  J. Am. Oil Chem. Soc. 43, 152A-154A (1966).

173a.   Annual Report of The Hormel Institute, 1956-57.

173b.   Annual Report of The Hormel Institute, 1957-58.

173c.   Annual Report of The Hormel Institute, 1958-59.

173d.   Annual Report of The Hormel Institute, 1959-60.

173e.   Annual Report of The Hormel Institute, 1960-61.

173f.    Annual Report of The Hormel Institute, 1961-62.

173g.   Annual Report of The Hormel Institute, 1962-63.

173h.   Annual Report of The Hormel Institute, 1963-64.

173i.    Annual Report of The Hormel Institute, 1964-65.

173j.    Annual Report of The Hormel Institute, 1965-66.

173k.   Ralph T. Holman.  Techniques of Biological Chemistry.  Review of book by R. T. Holman, Science 151, 678 (1965).

173l.    Ralph T. Holman.  Review of book "Analysis of Fats and Oils," Anal. Chem. 32 (11), 68A and 72A (1960).

173m.  B. Ahluwalia, J. J. Rahm, H. Mohrhauer and R. T. Holman.  Influence of Dietary Polyunsaturated Fatty Acids upon Fatty Acid Composition of Rat Testes.  J. Dairy Sci. 48, 819 (1965).

174.     Cecil B. Johnson and Ralph T. Holman.  Mass Spectrometry of Lipids.  II. Monoglycerides, Their Diacetyl Derivatives and Their Trimethylsilyl Ethers.  Lipids 1, 371-380 (1966).

175.     Terry M. Groff, Henry Rakoff and Ralph T. Holman.  Mass Spectrometry of Lipids.  Isomeric Methyl Nonynoates and the Corresponding Nonenoates and Dideutero-nonenoates.  Ark. Kemi 29, 179-190 (1968).

176.     Joseph J. Rahm and Ralph T. Holman.  Essential Fatty Acids. In "The Vitamins," Vol. III, Second Edition, Eds. W. H. Sebrell, Jr. and Robert S. Harris, Academic Press, New York, pp. 303-339 (1971).

177.     Howard W. Sprecher, H. J. Dutton, F. D. Gunstone, P. T. Sykes and Ralph T. Holman.  Metabolic Conversions and the Positional Distributions in Liver Lecithin of Some Unnatural Dienoic Acids in the Rat.  Lipids 2, 122-126 (1967).

178.     Hans Mohrhauer, Joseph J. Rahm, Joseph Seufert and Ralph T. Holman.  Metabolism of Linoleic Acid in Relation to Dietary Monoenoic Fatty Acids in the Rat.  J. Nutr. 91, 521-527 (1967).

179.     Hans Mohrhauer and Ralph T. Holman.  Metabolism of Linoleic Acid in Relation to Dietary Saturated Fatty Acids in the Rat.  J. Nutr. 91, 528-534 (1967).

180.     B. Ahluwalia, G. Pincus and R. T. Holman.  Essential Fatty Acid Deficiency and Its Effects upon Reproductive Organs of Male Rabbits.  J. Nutr. 92, 205-214 (1967).

181.     Ralph T. Holman.  The Role of Dietary Fat in Human Health.  A Report of the Food and Nutrition Board, National Academy of Sciences--National Research Council, Publication 575, written by the Committee on Fats in Human Nutrition,  pp. 1-32 (1958).

182.     Ralph T. Holman.  Dietary Fat and Human Health.  A Report of the Food and Nutrition Board, National Academy of Sciences--National Research Council, written by the Committee on Fats in Human Nutrition, Publication 1157, pp. 1-51 (1966).

183.     R. T. Holman.  Fat Metabolism.  Taped television lecture in Minnesota Feasibility Study, Austin Junior College - Rochester Junior College, August (1966).

184.     Kwok K. Sun and Ralph T. Holman.  Mass Spectrometry of Lipid Molecules.  J. Am. Oil Chem. Soc. 45, 810-817 (1968).

185.     Hans Mohrhauer, Kirsten Christiansen, Minerva V. Gan, Manfred Deubig and Ralph T. Holman.  Chain Elongation of Linoleic Acid and Its Inhibition by Other Fatty Acids in Vitro.  J. Biol. Chem. 242, 4507-4514 (1967).

186.     William W. Christie and Ralph T. Holman.  Synthesis and Characterization of the Complete Series of Methylene-Interrupted cis,cis-Octadecadienoic Acids.  Chem. Phys. Lipids 1, 407-423 (1967).

187.     Cecilia Pudelkewicz, Joseph Seufert and Ralph T. Holman.  Requirement of the Female Rat for Linoleic and Linolenic Acids.  J. Nutr. 94, 138-146 (1968).

188.     Cecelia Pudelkewicz and Ralph T. Holman.  Positional Distribution of Fatty Acids in Liver Lecithin of Rats as a Function of Dietary Linoleate or Linolenate.  Biochim. Biophys. Acta 152, 340-345 (1968).

189.     Yves L. Marcel and Ralph T. Holman.  Synthesis of 14C-Labelled Polyunsaturated Fatty Acids.  Chem. Phys. Lipids 2, 173-182 (1968).

190.     Ronald C. Reitz, William E. M. Lands, William W. Christie and Ralph T. Holman.  Effects of Ethylenic Bond Position upon Acyltransferase Activity with Isomeric cis,cis-Octadecadienoyl Coenzyme A Thiol Esters.  J. Biol. Chem. 243, 2241-2246 (1968).

191.     Hans Mohrhauer, Kirsten Christiansen, Minerva Gan, Manfred Deubig and Ralph T. Holman.  Improved Method for the Preparation of Malonyl Coenzyme A.  J. Lipid Res. 9, 398 (1968).

192.     Kirsten Christiansen, Yves Marcel, Minerva V. Gan, Hans Mohrhauer and Ralph T. Holman.  Chain Elongation of - and -Linolenic Acids and the Effect of Other Fatty Acids on Their Conversion in vitro.  J. Biol. Chem. 243, 2969-2974  (1968).

193.     Y. L. Marcel, K. Christiansen and R. T. Holman.  The Preferred Metabolic Pathway from Linoleic Acid to Arachidonic Acid in vitro.  Biochim. Biophys.  Acta 164, 25-34 (1968).

194.     B. Ahluwalia and R. T. Holman.  Fatty Acid Composition of Lipids of Bull, Boar, Rabbit and Human Semen.  J. Reprod. Fert. 18, 431-437 (1969).

195.     Ralph T. Holman, Peter O. Egwim and William W. Christie.  Substrate Specificity of Soybean Lipoxidase.  J. Biol. Chem. 244, 1149-1151 (1969).

196.     Ralph T. Holman.  Essential Fatty Acid Deficiency.  Prog. Chem. Fats Other Lipids 9, 275-348 (1971).

197.     Editor:  Progress in the Chemistry of Fats and Other Lipids, Pergamon Press, Oxford, Vol. 7, 308 pages (1964).

198.     Editor:  Progress in the Chemistry of Fats and Other Lipids, Pergamon Press, Oxford, Vol. 8, 436 pages (1966).

199.     Editor:  Progress in the Chemistry of Fats and Other Lipids, Pergamon Press, Oxford, Vol. 9, 718 pages (1971).

200.     Editor:  Progress in the Chemistry of Fats and Other Lipids, Pergamon Press,  Oxford, Vol. 10, 466 pages (1970).

201.     W. W. Christie, D. Rebello and Ralph T. Holman.  Mass Spectrometry of Derivatives of Cyclopentenyl Fatty Acids.  Lipids 4, 229-231 (1969).

202.     Kirsten Christiansen, V. Mahadevan, C. V. Viswanathan and R. T. Holman.  Mass Spectrometry of Long-Chain Aliphatic Aldehydes, Dimethyl Acetals and  Alk-1-enyl Ethers.  Lipids 4, 421-427 (1969).

203.     Gustav Graff, Yves L. Marcel and Ralph T. Holman.  Analysis of Labeled Fatty Acids by Argentation Chromatography of Their Methyl Esters on Glass Fiber Sheets.  J. Chromatogr. Sci. 7, 298-299 (1969).

204.     Kirsten Christiansen, Minerva V. Gan and Ralph T. Holman.  Sex Differences in the Metabolism of Fatty Acids in vitro.  Biochim. Biophys. Acta 187, 19-25 (1969).

205.     Kwok K. Sun, Herbert W. Hayes and Ralph T. Holman.  Thermal and Mass Spectrometric Fragmentation of Esters of Deuterated Long Chain Carboxylic Acids. Org. Mass Spectrom. 3, 1035-1042 (1970).

206.     H. M. Jenkin, L. E. Anderson, R. T. Holman, I. A. Ismail and F. D. Gunstone. Effect of Isomeric cis-Octadecenoic Acids on the Growth of Leptospira interrogans Serotype patoc.  J. Bacteriol. 98, 1026-1029 (1969).

207.     W. J. Baumann, J. Seufert, H. W. Hayes and R. T. Holman.  Mass Spectrometric Analysis of Long-Chain Esters of Diols.  J. Lipid Res. 10, 703-709 (1969).

208.     H. M. Jenkin, L. E. Anderson, R. T. Holman, I. A. Ismail and F. D. Gunstone.  The Effect of Isomeric cis-Octadecenoic Acids on the Growth of Monkey Kidney Cells (LLC-MK2).  Exp. Cell Res. 59, 1-5 (1970).

209.     Lars Soderhjelm, Hilda F. Wiese and Ralph T. Holman.  The Role of Polyunsaturated Acids in Human Nutrition and Metabolism.  Prog. Chem. Fats Other Lipids 9, 555-585 (1971).

210.     Ralph T. Holman.  Biological Activities of and Requirements for Polyunsaturated Acids.  Prog. Chem. Fats Other Lipids 9, 607-682 (1971).

211.     Ralph T. Holman.  Metabolic Conversions of Polyunsaturated Fatty Acids.  In "Proceedings of the 1968 Deuel Conference on Lipids:  The Turnover of Lipids and Lipoproteins," Chapter 8, Eds. G. Cowgill, D. L. Estrich and P. D. Wood, U. S. Government Printing Office, pp. 75-77 (1969).

212.     John R. Paulsrud, Sheila E. Stewart, Gustav Graff and Ralph T. Holman.  Desaturation of Saturated Fatty Acids by Rat Liver Microsomes.  Lipids 5, 611-616 (1970).

213.     Gustav Graff, Patricia Szczepanik, Peter D. Klein, J. R. Chipault and Ralph T. Holman.  Identification and Characterization of Fully Deuterated Fatty Acids Isolated from Scenedesmus obliquus Cultured in Deuterium Oxide.  Lipids 5, 786-792 (1970).

214.     W. M. Lauer, A. J. Aasen, G. Graff and R. T. Holman.  Mass Spectrometry of Triglycerides:  I.  Structural Effects.  Lipids 5, 861-868 (1970).

215.     A. J. Aasen, W. M. Lauer and R. T. Holman.  Mass Spectrometry of Triglycerides:  II.  Specifically Deuterated Triglycerides and Elucidation of Fragmentation Mechanisms.  Lipids 5, 869-877 (1970).

216.     A. J. Aasen, H. H. Hofstetter, B. T. R. Iyengar and R. T. Holman.  Identification and Analysis of Wax Esters by Mass Spectrometry.  Lipids 6, 502-507 (1971).

217.     John K. G. Kramer, Wolfgang J. Baumann and Ralph T. Holman.  Mass Spectrometric Analysis of Long Chain Alk-1-enyl Ether Esters and Alkyl Ether Esters of Diols.  Lipids 6, 492-501 (1971).

218.     Ralph T. Holman, Herbert W. Hayes, and W. W. Christie.  Mass Spectra of Cyclopentenylic Acids and Their Derivatives.  Arch. Mass Spectral Data 2, 4-27 (1971).

219.     Editor:  Progress in the Chemistry of Fats and Other Lipids, Pergamon Press, Oxford, Vol. 11, 424 pages (1971).

220.     Wayne H. Heimermann and Ralph T. Holman.  Highly Optically Active Triglycerides of Sebastiana ligustrina and Related Species.  Phytochemistry 11, 799-802 (1972).

221.     Ralph T. Holman and Patrick C. Nichols.  Characterization of the Lipids of Some Orchids.  Phytochemistry 11, 333-337 (1972).

222.     Gustav Graff, Herbert W. Hayes and Ralph T. Holman.  Mass Spectra of Methyl Esters of Perdeuterio Fatty Acids.  Arch. Mass Spectral Data 3, 160-165 (1972).

223.     A. J. Aasen, H. W. Hayes and R. T. Holman.  Mass Spectra of Deuterium Labeled Triglycerides.  Arch. Mass Spectral Data 3, 166-191 (1972).

224.     A. Strocchi and R. T. Holman.  Analysis of Fatty Acids of Butterfat. Riv. Ital. Sostanze Grasse 48, 617-622 (1971).
    
225.     John R. Paulsrud, Leslie Pensler, Charles F. Whitten, Sheila Stewart and Ralph T. Holman.  Essential Fatty Acid Deficiency in Infants Induced by Fat-Free Intravenous Feeding.  Am. J. Clin. Nutr. 25, 897-904 (1972).

226.     Huei-che Chang and Ralph T. Holman.  Chain Shortening of Acyl-Coenzyme A by Rat Liver Microsomes.  Biochim. Biophys. Acta 280, 17-21 (1972). 

227.     Robert G. Jensen, Dennis T. Gordon, Wayne H. Heimermann and Ralph T. Holman.  Specificity of Geotrichum candidum Lipase with Respect to Double Bond Position in Triglycerides Containing cis-Octadecenoic Acids.  Lipids 7, 738-741 (1972).

228.     Huei-che Chang, James Janke, Fred Pusch and Ralph T. Holman.  Effect of Double and Triple Bonds in Fatty Acid Inhibitors upon Desaturation of Stearic Acid by Rat Liver Microsomes.  Biochim. Biophys. Acta 306, 21-25 (1973).

229.     Wayne H. Heimermann, Ralph T. Holman, Dennis T. Gordon, Doris E. Kowalyshyn and Robert G. Jensen.  Effect of Double Bond Position in Octadecenoates upon Hydrolysis of Pancreatic Lipase.  Lipids 8, 45-47 (1973).

230.     Patrick C. Nichols and Ralph T. Holman.  Pyrolysis of Saturated Triglycerides.  Lipids 7, 773-779 (1972).

231.     Ralph T. Holman.  Essential Fatty Acid Deficiency in Humans.  In "Dietary Lipids and Postnatal Development,"  Raven Press, New York, pp. 127-143 (1973).

232.     Ralph T. Holman and Wayne H. Heimermann.  Identification of Components of Orchid Fragrances by Gas Chromatography-Mass Spectrometry.  Am. Orchid Soc. Bull. 42, 678-682 (1973).

233.     Bengt A. Andersson and Ralph T. Holman.  Pyrrolidides for Mass Spectrometric Determination of the Position of the Double Bond in Monounsaturated Fatty Acids.  Lipids 9, 185-190 (1974).
    
234.     B. A. Andersson, W. H. Heimermann and R. T. Holman.  Comparison of Pyrrolidides with Other Amides for Mass Spectral Determination of Structure of Unsaturated Fatty Acids.  Lipids 9, 443-449 (1974).

235.     Wolfgang J. Baumann, Arne J. Aasen, John K. G. Kramer and Ralph T. Holman.  Evidence for the Electron Impact Induced Formation of Prominent Cyclic Acetal Ions from Aliphatic Ester Lipids.  J. Org. Chem. 38, 3767-3771 (1973).

236.     Ralph T. Holman.  Significance of Essential Fatty Acids in Human Nutrition  In "Lipids," Vol. 1, Eds. R. Paoletti, G. Porcellati and G. Jacini, Raven Press, New York, pp. 215-226 (1976).

237.     Bengt A. Andersson and Ralph T. Holman.  Mass Spectrometric Localization of Methyl Branching in Fatty Acids Using Acylpyrrolidines.  Lipids 10, 716-718 (1975).

238.     Bengt A. Andersson, William W. Christie and Ralph T. Holman.  Mass Spectrometric Determination of Positions of Double Bonds in Polyunsaturated Fatty Acid Pyrrolidides.  Lipids 10, 215-219 (1975).

239.     Ralph T. Holman.  Role of Essential Fatty Acids in Human Nutrition.  Yukagaku (J. Jpn. Oil Chem. Soc.) 24, 139-144 (1975).

240.     Ralph T. Holman and Wayne H. Heimermann.  The Chemical Composition of Fragrances of Some Orchids.  In "First Symposium on the Scientific Aspects of Orchids," Eds. H. Harry Szmant and James Wemple, University of Detroit Publ., pp. 75-89 (1976).

241.     L. B. Thien, W. H. Heimermann and R. T. Holman.  Floral Odors and Quantitative Taxonomy of Magnolia and Liriodendron.  Taxon 24, 557-568 (1975).

242.     Ralph T. Holman.  Deficiency of Essential Fatty Acids in Humans.  In "Essential Fatty Acids," Proc. of the Miles Symposium '75, Ed. W. W. Hawkins, The Nutrition Society of Canada, pp. 45-58 (1976).

243.     Pilar Teresa Garcia, W. W. Christie, Howard M. Jenkin, Lloyd Anderson and Ralph T. Holman.  The Isomerization of 2,5- and 9,12-Octadecadienoic Acids by an Extract of Butyrivibrio fibrisolvens.  Biochim. Biophys. Acta 424, 296-302 (1976).

244.     Ralph T. Holman.  Function and Biologic Activities of Essential Fatty Acids in Man.  In "Fat Emulsions in Parenteral Nutrition," AMA Symposium on Fat Emulsion in Parenteral Nutrition, June 5-6, 1975, Eds. H. C. Meng and Douglas W. Wilmore, American Medical Assoc., Chicago, IL, pp. 5-14 (1976).

245.     Editor:  Progress in the Chemistry of Fats and Other Lipids, Pergamon Press, Oxford, Vol. 12, 307 pages (1972).

246.     Editor:  Progress in the Chemistry of Fats and Other Lipids, Pergamon Press, Oxford, Vol. 13, 283 pages (1973).

247.     Editor:  Progress in the Chemistry of Fats and Other Lipids, Pergamon Press, Oxford, Vol. 14, 299 pages (1975).

248.     A. J. Valicenti and R. T. Holman.  Oxidation of Long-Chain Alcohols to Aldehydes by the Dipyridine Chromic Anhydride Complex.  Chem. Phys. Lipids 17, 389-392 (1976).

249.     Jerry Darsie, Susan K. Gosha and Ralph T. Holman.  Induction of Abnormal Fatty Acid Metabolism and Essential Fatty Acid Deficiency in Rats by Dietary DDT.  Arch. Biochem. Biophys. 175, 262-269 (1976).

250.     R. T. Holman.  Biological Significance of the Position of the Double Bonds in Fatty Acids and Isomerism:  Effect on Metabolism and Function of Unsaturated Fatty Acids.  In "Encyclopedia of Food Science," Vol. 3, Eds. Martin S.  Peterson and Arnold H. Johnson, AVI Publ. Co., Westport, CT, pp. 84-87 and 423-426, respectively (1978).

251.     Ralph T. Holman.  Cultivation of Cypripedium calceolus and Cypripedium reginae.  Am. Orchid Soc. Bull. 45, 415-422 (1976).

252.     Ralph T. Holman.  The Deficiency of Essential Fatty Acids.  In "Polyunsaturated Fatty Acids," Eds. Wolf-H. Kunau and Ralph T. Holman, AOCS Monograph No. 4, American Oil Chemists' Society Publishers, Champaign, IL, pp. 163-182 (1977).

253.     Carl E. Hunt, Rolf R. Engel, Siv Modler, Wade Hamilton, Susan Bissen and Ralph T. Holman.  Essential Fatty Acid Deficiency in Neonates:  Inability to Reverse Deficiency by Topical Applications of EFA-Rich Oil.  J. Pediatr. 92, 603-607 (1978).

254.     W. O. Caster, James W. Andrews, Jr., Hans Mohrhauer and Ralph T. Holman. Effect of Essential and Nonessential Fatty Acids in Complex Mixture on Fatty
      Acid Composition of Liver Lipids.  J. Nutr. 106, 1809-1816 (1976).

255.     John K. G. Kramer, Ralph T. Holman and Wolfgang J. Baumann.  Mass Spectrometric Analysis of Mono- and Dialkyl Ethers of Diols.  Lipids 6,
      727-733 (1971).

256.     R. T. Holman.  The Effect of Structure of Unsaturated Fatty Acids upon Chemical and Biochemical Reactions.  Transactions in the symposium on "Lipoperoxidation in Disease," August 26, 1976, published by Tokyo Tanabe Company Limited, Tokyo, Japan (1978).

257.     R. T. Holman.  Essential Fatty Acid Deficiency in Animals.  In "CRC Handbook Series in Nutrition and Food, Section E:  Nutritional Disorders," Vol. 2,  Ed. M. Rechcigl, Jr., CRC Press, Cleveland, OH, pp. 491-515 (1978).

258.     R. T. Holman.  Essential Fatty Acids in Human Nutrition.  In "Advances in Experimental Medicine" (Function and Biosynthesis of Lipids), Ed. Nicolas G. Bazan, Rodolfo R. Brenner and Norman M. Giusto, Plenum Publ. Corp., New York, pp. 515-534 (1977).

259.     Ralph T. Holman.  Grow the State Flower in Your Backyard.  Minn. Heritage Series, No. 2, Minn. Dept. of Natural Resources, pp. 6-7 (1976).

260.     Ralph T. Holman.  Grow Minnesota's Regal Flower.  In "The Minnesota Volunteer," Ed. John G. McKane, Official Publ. Minn. Dept. of Natural Resources, St. Paul, MN, Vol. 39, #227, pp. 52-57 (1976).

261.     R. T. Holman.  Quantitative Chemical Taxonomy Based upon Composition of Lipids. Prog. Chem. Fats Other Lipids 16, 9-29 (1978).

262.     R. T. Holman.  Essential Fatty Acid Deficiency in Humans.  In "CRC Handbook Series in Nutrition and Food, Section E:  Nutritional Disorders," Vol. 3, Ed. M. Rechcigl, Jr., CRC Press, Cleveland, OH, pp. 335-368 (1978).

263.     Ralph T. Holman.  Function and Metabolism of Essential Fatty Acids.  In "Nutrition in Transition:  Proceedings, Western Hemisphere Nutrition Congress V," Eds. Philip L. White and Nancy Selvey, American Medical Assoc. Publ., Monroe, WI, pp. 77-87 (1978).

264.     Anthony J. Valicenti, Clifford J. Chapman, Ralph T. Holman and Jacques R. Chipault.  Mass Spectrometric Identification of C20 Fatty Acids in Bovine Lens Using the Pyrrolidide Derivative.  Lipids 13, 190-194 (1978).

265.     Ralph T. Holman.  How Essential Are Essential Fatty Acids?  J. Am. Oil Chem. Soc. 55, 774A-782A (1978); translated into Dutch and French 1984.

265a.   Ralph T. Holman.  Que Tan Esenciales Son Los Acidos Grasos Esenciales?  Arch. Latinam. Nutr. (In Spanish) 29, 11-38 (1979).

266.     Anthony J. Valicenti, Wayne H. Heimermann and Ralph T. Holman.  Mass Spectrometric Location of Triple Bonds in Fatty Acids and Fragmentation Mechanisms of N-Acylpyrrolidines.  J. Org. Chem. 44, 1068-1073 (1979).

267.     Carl E. Hunt, Rolf R. Engel and Ralph T. Holman.  Letter to the Editor.  J. Pediatr. 93, 1069 (1978).

268.     Eldon G. Hill, Susan B. Johnson and Ralph T. Holman.  Intensification of Essential Fatty Acid Deficiency in the Rat by Dietary trans Fatty Acids.  J. Nutr. 109, 1759-1765 (1979).

269.     Ralph T. Holman, Lowell Smythe and Susan Johnson.  Effect of Sex and Age on Fatty Acid Composition of Human Serum Lipids.  Am. J. Clin. Nutr. 32, 2390-2399 (1979).

270.     Ralph T. Holman.  The Importance of Double Bond Position in the Metabolism of Unsaturated Fatty Acids.  In "Geometrical and Positional Fatty Acid Isomers," Chapter 10, AOCS Monograph, Eds. E. A. Emken and H. J. Dutton, American Oil Chemists' Society, Champaign, IL, pp. 283-301 (1979).

271.     Bruce A. Evans, Jeffrey K. Yao, Ralph T. Holman, W. Stephen Brimijoin, Edward H. Lambert and Peter James Dyck.  Structural and Biochemical Effects of Essential Fatty Acid Deficiency on Peripheral Nerve.  J. Neuropathol. Exp. Neurol. 39, 683-691 (1980).

272.     Eldon G. Hill and Ralph T. Holman.  Effect of Dietary Protein Level upon Essential Fatty Acid (EFA) Deficiency.  J. Nutr. 110, 1057-1060 (1980).

273.     Elizabeth S. Swanson, William P. Cunningham and Ralph T. Holman. Ultrastructure of Glandular Ovarian Trichomes of Cypripedium calceolus and C. reginae (Orchidaceae).  Am. J. Bot. 67, 784-789 (1980).

274.     Ralph T. Holman.  Essential Fatty Acid Deficiency.  In "Total Parenteral Nutrition," Proc. of the Symposium on Total Parenteral Nutrition sponsored by the Food Science Committee, Council on Foods and Nutrition of the Am. Med. Assoc., Nashville, TN, 1972, Eds. Philip L. White and Margarita E. Nagy, Publishing Sciences Group, Inc., Acton, MA, pp. 214-220 (1974).

275.     Bengt A. Andersson, Ralph T. Holman, Lennart Lundgren and Gunnar Stenhagen.   Capillary Gas Chromatograms of Leaf Volatiles.  A Possible Aid to Breeders for Pest and Disease Resistance.  J. Agr. Food Chem. 28, 985-989 (1980).

276.     M. M. Mahfouz, A. J. Valicenti and R. T. Holman.  Desaturation of Isomeric trans-Octadecenoic Acids by Rat Liver Microsomes.  Biochim. Biophys. Acta
      618, 1-12 (1980).

277.     Kensuke Kameda, A. J. Valicenti and Ralph T. Holman.  Chain Elongation of trans-Octadecenoic Acid Isomers in Rat Liver Microsomes.  Biochim. Biophys.  Acta 618, 13-17 (1980).

278.     M. M. Mahfouz, S. Johnson and R. T. Holman.  The Effect of Isomeric trans-18:1 Acids on the Desaturation of Palmitic, Linoleic and Eicosa-8,11,14-trienoic Acids by Rat Liver Microsomes.  Lipids 15, 100-107 (1980).

279.     Paul L. Ogburn, Jr., Susan B. Johnson, Preston P. Williams and Ralph T. Holman. Levels of Free Fatty Acids and Arachidonic Acid in Pregnancy and Labor.  J. Lab. Clin. Med. 95, 943-949 (1980).

280.     John D. Lloyd-Still, Susan B. Johnson and Ralph T. Holman.  Essential Fatty  Acid Status in Cystic Fibrosis and the Effects of Safflower Oil  Supplementation.  Am. J. Clin. Nutr. 34, 1-7 (1981).

281.     M. Mahfouz and R. T. Holman.  Desaturation of Isomeric cis 18:1 Acids.  Lipids 15, 63-65 (1980).

282.     Ralph T. Holman.  Answers to Questions Never Really Asked.  University of Minnesota Annual Report, pp. 24-26 (1979).

283.     Ralph A. Nelson, Diane M. Huse, Ralph T. Holman, Barbara O. Kimbrough, Heinz W. Wahner, C. Wayne Callaway and Aldine B. Hayles.  Nutrition, Metabolism, Body Composition and Response to the Ketogenic Diet in Prader-Willi Syndrome.  In "The Prader Willi Syndrome," Chapter 8, Eds. V. A. Holm and P. L. Pipes, University Park Press, Baltimore, MD, pp. 105-120 (1981). 

284.     Jeffrey K. Yao, Ralph T. Holman, Michael F. Lubozynski and Peter James Dyck.  Changes in Fatty Acid Composition of Peripheral Nerve Myelin in Essential Fatty Acid Deficiency.  Arch. Biochem. Biophys. 204, 175-180 (1980).

285.     M. Mahfouz, S. Johnson and R. T. Holman.  Inhibition of Desaturation of Palmitic, Linoleic and Eicosa-8,11,14-trienoic Acids In Vitro by Isomeric cis-Octadecenoic Acids.  Biochim. Biophys. Acta 663, 58-68 (1981).

286.     R. T. Holman.  New Challenges for Lipids.  J. Am. Oil Chem. Soc. 57, 30A (1980).

287.     Ralph T. Holman, Susan B. Johnson, Osvaldo Mercuri, Herminia J. Itarte, Maria A. Rodrigo and Maria E. De Tomas.  Essential Fatty Acid Deficiency in Malnourished Children.  Am. J. Clin. Nutr. 34, 1534-1539 (1981).

288.     R. T. Holman and M. M. Mahfouz.  Cis- and trans-Octadecenoic Acids as Precursors of Polyunsaturated Acids.  Prog. Lipid Res. 20, 151-156 (1981).

289.     Ralph T. Holman and Susan Johnson.  Changes in Essential Fatty Acid Profile of Serum Phospholipids in Human Disease.  Prog. Lipid Res. 20, 67-73 (1981).

290.     Ralph T. Holman.  Effect of Dietary Trans Fatty Acids Upon Prostaglandin Precursors.  In "Nutritional Factors: Modulating Effects on Metabolic Processes," Miles Symposium Series, No. 13, Ed. R. F. Beers, Jr. and E. G. Bassett, Raven Press, NY, pp. 523-537 (1981).

291.     A. J. Valicenti, F. J. Pusch and R. T. Holman.  Synthesis of [1-14C]Labeled Isomers of cis- and trans-Octadecenoic Acids and Synthesis of Octadecynoic Acids.  Prog. Lipid Res. 20, 763-767 (1981).

292.     T. Riisom and R. T. Holman.  Incorporation into Lipid Classes of Products from Microsomal Desaturation of Isomeric trans-Octadecenoic Acids.  Lipids 16, 647-654 (1981).

293.     Peter James Dyck, Jeffrey K. Yao, Donald E. Knickerbocker, Ralph T. Holman, Manuel R. Gomez, Alvin B. Hayles and Edward H. Lambert.  Multisystem Neuronal Degeneration, Hepatosplenomegaly and Adrenocortical Deficiency Associated with Reduced Tissue Arachidonic Acid.  Neurology 31, 925-934 (1981).

294.     O. Hernell, G. Holmgren, S. F. Jagell, S. B. Johnson and R. T. Holman. Suspected Faulty Essential Fatty Acid Metabolism in Sjogren-Larsson Syndrome.  Pediatr. Res. 16, 45-49 (1982).

295.     Ralph T. Holman.  Polyunsaturated Fatty Acid Profiles in Human Disease.  In "Current Topics in Nutrition and Disease, New Trends in Nutrition, Lipid  Research, and Cardiovascular Diseases," Vol. 5, Eds. N. G. Bazan, R. Paoletti and J. M. Iacono, Alan R. Liss, Inc., New York, pp. 25-42 (1981).

296.     Ralph T. Holman, Susan B. Johnson and Terry F. Hatch.  A Case of Human Linolenic Acid Deficiency Involving Neurological Abnormalities.  Am. J. Clin. Nutr. 35, 617-623 (1982).

297.     Editor:  Progress in the Chemistry of Fats and Other Lipids, Pergamon Press, Vol. 15, 391 pages (1979).

298.     Editor:  Progress in the Chemistry of Fats and Other Lipids, Pergamon Press, Vol. 16, 317 pages (1978).

299.     Editor:  Progress in Lipid Research, Pergamon Press, Vol. 17, 427 pages (1980).

300.     Tom Riisom, Susan Johnson, Eldon G. Hill and Ralph T. Holman.  Effects of Experimental Diabetes on the Essential Fatty Acid-Deficient Rat.  J. Lab. Clin. Med. 98, 764-775 (1981).

301.     Ralph T. Holman, Henry W. Blackburn, W. Eugene Cornatzer, P. Vincent Hegarty and James Zavoral.  The Amount and Degree of Unsaturation of Dietary Fat.  Proceedings of Symposium "Revised U.S. Dietary Goals:  Implication for the Nation's Health," held at Earle Brown Continuation Center, University of Minnesota, St. Paul, MN, November 10, 1978, pp. 10-17.

302.     Larry D. Lawson and Ralph T. Holman.  -Oxidation of the Geometric and Positional Isomers of Octadecenoic Acid by Rat Heart and Liver Mitochondria.  Biochim. Biophys. Acta  665, 60-65 (1981).

303.     Ralph T. Holman, William P. Cunningham and Elizabeth S. Swanson.  A Closer Look at the Glandular Hairs on the Ovaries of Cypripediums.  Am. Orchid Soc.  Bull. 50, 683-687 (1981).

304.     Ralph T. Holman, Susan B. Johnson, Jonathan M. Gerrard, S. Michael Mauer, Susan Kupcho-Sandberg and David M. Brown.  Arachidonic Acid Deficiency in Streptozotocin-induced Diabetes.  Proc. Natl. Acad. Sci. USA 80, 2375-2379 (1983). 

305.     Irma G. Rieckehoff, Ralph T. Holman and G. O. Burr.  Polyethenoid Fatty Acid Metabolism.  Effect of Dietary Fat on Polyethenoid Fatty Acids of Rat Tissues (reprinted as a Nutrition Classic).  Nutr. Rev. 38, 247-250 (1980).

306.     R. T. Holman.  The Ratio of Trienoic:Tetraenoic Acids in Tissue Lipids as a Measure of Essential Fatty Acid Requirement (printed as a Citation Classic).  Current Contents 12, 18 (1981).

307.     Ralph T. Holman.  Essential Fatty Acids in Nutrition and Disease.  Society of Chemical Industry Oils and Fats Group International Lecture, 4/13/81.  Chem. Ind. 704-709 (1981).

308.     Editor:  Progress in Lipid Research, Pergamon Press, Oxford, Vol. 18, 239 pages (1981).

309.     Editor:  Progress in Lipid Research, Pergamon Press, Oxford, Vol. 19, 240 pages (1982).

310.     Eldon G. Hill, Susan B. Johnson, Larry D. Lawson, M. M. Mahfouz and Ralph T. Holman.  Perturbation of the Metabolism of Essential Fatty Acids by Dietary Partially Hydrogenated Vegetable Oil.  Proc. Natl. Acad. Sci. USA 79,  953-957 (1982).

311.     Paul L. Ogburn, Jr., Harvey Sharp, John D. Lloyd-Still, Susan B. Johnson and Ralph T. Holman.  Abnormal Polyunsaturated Fatty Acid Patterns of Serum Lipids in Reye's Syndrome.  Proc. Natl. Acad. Sci. USA 79, 908-911 (1982).

312.     Ralph T. Holman and Susan B. Johnson.  Essential Fatty Acid Deficiencies in Man.  In AOCS Monograph "Dietary Fats and Health," Eds. E. G. Perkins and W. J. Visek, American Oil Chemists' Society, Champaign, Illinois, pp. 247-266 (1983), and as the Hogan Memorial Lecture, University of Missouri, 1982.

313.     R. T. Holman, M. M. Mahfouz, L. D. Lawson and E. G. Hill.  Metabolic Effects of Isomeric Octadecenoic Acids.  In AOCS Monograph "Dietary Fats and Health," Eds. E. G. Perkins and W. J. Visek, American Oil Chemists' Society, Champaign, Illinois, pp. 320-340 (1983), and as the Hogan Memorial Lecture, University of Missouri, 1982.

314.     Ralph T. Holman.  Studies on the Fragrances of North American Terrestrial Orchids.  In "North American Terrestrial Orchids Symposium II, Proceedings and Lecture, October 1981," Ed. Elmer Plaxton, Michigan Orchid Society, Livonia, MI, pp. 32-40 (1983).

315.     Editor: Progress in Lipid Research, Pergamon Press, Vol. 20, 911 pages (1981).

316.     Ralph T. Holman and Susan B. Johnson.  Linolenic Acid Deficiency in Man.  Nutr. Rev. 40, 144-147 (1982).

317.     Larry D. Lawson, Eldon G. Hill and Ralph T. Holman.  Accumulation and Depletion of trans-Octadecenoic Acid in Rat Peripheral Nerve Phospholipid.  Biochim. Biophys. Acta 712, 117-122 (1982).

318.     Ralph T. Holman.  Clinical Linolenic Acid Deficiency.  In "Nutrition and the M.D.," Vol. 8, No. 10, p. 4 (1982).
          
319.     Ralph T. Holman.  Fragrance in the Lives and Identities of Orchids.  In (a) "Houston Happenings," Vol. 10, No. 5, pp. 2-3 (1982); (b) Orchidian, issue 3, p. 62 (1982); (c) The Mid-American, pp. 5-6 (1983); (d) J. Orchid Species Soc. Victoria, Vol. 2, #3, pp. 3-4, July 1983; (e) The Orchadian, J. Austral. Native Orchid Soc., 7 No. 10, pp. 240-241 (1983).

320.     Ralph T. Holman, Susan B. Johnson and Terry F. Hatch.  Letter to the Editor:   Reply to the letter by Bozian and Moussavian.  Am. J. Clin. Nutr. 36, 1254-1255 (1982).

321.     Ralph T. Holman, Susan B. Johnson and Terry F. Hatch.  Letter to the Editor:  Reply to letter by H. C. Meng.  Am. J. Clin. Nutr. 37, 159-160 (1983).

322.     Jeffrey K. Yao, Kevin P. Cannon, Ralph T. Holman and Peter James Dyck.  Effects of Polyunsaturated Fatty Acid Diets on Plasma Lipids of Patients with Adreno-Multineuronal Degeneration, Heptasplenomegaly and Fatty Acid Derangement.  J. Neurol. Sci. 62 67-76 (1983).

323.     Larry D. Lawson, Eldon G. Hill and Ralph T. Holman.  Suppression of Arachidonic Acid in Lipids of Rat Tissues by Dietary Mixed Isomeric cis and trans Octadecenoates.  J. Nutr. 113, 1827-1835 (1983).

324.     R. T. Holman and S. B. Johnson.  The Effects of Disease and Nutrition upon Metabolism of Polyunsaturated Fatty Acids.  In "Fats for the Future," The Proceedings of the International Conference on Oils, Fats and Waxes, Auckland 1983, Eds. S. G. Brooker, A. Renwick, S. F. Hannan and L. Eyres, Duromark Publishing Co., Auckland, New Zealand, pp. 206-212 (1983).

325.     A. Valicenti, F. J. Pusch and R. T. Holman.  Synthesis of Octadecynoic Acids and [1-14C]Labeled Isomers of Octadecenoic Acids.  Lipids 20 234-242 (1985).

326.     H. J. Dutton, S. B. Johnson, W. H. Heimermann, F. J. Pusch, R. T. Holman and F. D. Gunstone.  Determination of Structure and Composition of Mixed Octadecadienoic Acids via Ozonolysis, Gas Chromatography and Computer Solution of Simultaneous Equations.  Proceedings of the 16th ISF Congress, Budapest, 1983. Edited by N. Hollo, 2 vol., pp. 61-77 (1985).


327.     Paul L. Ogburn, Preston P. Williams, Susan B. Johnson and Ralph T. Holman.  Serum Arachidonic Acid Levels in Normal and Preeclamptic Pregnancies.  Am. J. Obstetr. Gynecol. 148, 5-9 (1984).

328.     Tim R. Kramer, Mary Briske-Anderson, Susan B. Johnson and Ralph T. Holman. Influence of Reduced Food Intake on Polyunsaturated Fatty Acid Metabolism in Zinc-Deficient Rats.  J. Nutr. 114, 1224-1230 (1984).

329.     Tim R. Kramer, Mary Briske-Anderson, Susan B. Johnson and Ralph T. Holman.  Effects of Biotin Deficiency on Polyunsaturated Fatty Acid Metabolism in Rats.  J. Nutr. 114, 2047-2052 (1984).

330.     Larry D. Lawson, Eldon G. Hill and Ralph T. Holman.  Dietary Fats Containing Concentrates of cis or trans Octadecenoates and the Patterns of Polyunsaturated Fatty Acids of Liver Phospholipids.  Lipids 20, 262-267 (1985).

331.     Ralph T. Holman.  Influence of Hydrogenated Fats on the Metabolism of Polyunsaturated Fatty Acids.  In "The Role of Fats in Human Nutrition," Edited by F. B Padley, J. Podmore, J. P. Brun, R. Burt and B. W. Nichols, Society of Chemical Industry, London, England, pp. 48-61 (1985).

332.     Ralph T. Holman, Paul L. Ogburn, Jr. and Susan B. Johnson.  Nonesterified Fatty Acids as Toxins Contributing to the Pathogenesis of Reye's Syndrome and  Other Microvesicular Lipid Hepatic Diseases.  In "Reye's Syndrome IV, Proceedings of the 4th International Conference on Reye's Syndrome" edited by J. Dennis Pollack, National Reye's Syndrome Foundation, Bryan, OH, pp. 163-189 (1985).

333.     Eric Hagsater and Ralph T. Holman.  Epidendrum durangense, A New Species from Western Mexico.  Orquidea (Mex.) 9(2), 299-312 (1984).

334.     Patrick Kemp, David J. Lander and R. T. Holman.  The Hydrogenation of the Series of Methylene-Interrupted cis,cis-Octadecadienoic Acids by Pure Cultures of Six Rumen Bacteria.  Br. J. Nutr. 52, 171-177 (1984).

335.     Ralph T. Holman.  Control of Polyunsaturated Acids in Tissue Lipids. J. Am. College Nutr. 5, 236-265 (1986).

336.     Susan B. Johnson, Ellen Gordon, Craig McClain, Graeme Low and Ralph T. Holman.  Abnormal Polyunsaturated Fatty Acid Patterns of Serum Lipids in Alcoholism and Cirrhosis:  Arachidonic Acid Deficiency in Cirrhosis. Proc. Natl. Acad. Sci. 82, 1815-1818 (1985).

337.     Donald M. Mock, David L. Baswell, Herman Baker, Ralph T. Holman and Lawrence Sweetman.  Biotin Deficiency Complicating Parenteral Alimentation:  Diagnosis, Metabolic Repercussions, and Treatment.  J. Pediatr. 106, 762-769 (1985).

338.     Donald M. Mock, David L. Baswell, Herman Baker, Ralph T. Holman and Lawrence Sweetman.  Biotin Deficiency Complicating Parenteral Alimentation:  Diagnosis, Metabolic Repercussions, and Treatment.  N. Y. Acad. Sci., 447, 314-334 (1985).

339.     Tim R. Kramer, Mary Briske-Anderson, Susan B. Johnson and Ralph T. Holman.  Polyunsaturated Fatty Acid Patterns in Lymphoid and Nonlymphoid Tissues of Zinc Deficient and Pair-Fed Rats.  Nutr. Res. 6, 1063-1064 (1986).

340.     T. R. Kramer, M. Briske-Anderson, S. B. Johnson and R. T. Holman.  Reply to the Letter by Drs. Cunnane and Horrobin.  J. Nutr. 115, 502-503 (1985).

341.     Ralph T. Holman and Armand B. Christophe.  Human Essential Fatty Acid Deficiencies of Dietary and Metabolic Origin.  In "Clinical Studies in Medical Biochemistry," Eds. Robert H. Glew and Stephen P. Peters, Oxford University Press, New York, pp. 215-224 (1987).

342.     Ralph T. Holman.  Nutritional and Biochemical Evidences of Acyl Interaction with Respect to Essential Polyunsaturated Fatty Acids.  Prog. Lipid Res. 25, 29-39 (1986).

343.     Alan R. Sinaiko, Ralph T. Holman and Thomas P. Green.  Effectiveness of Dietary Essential Fatty Acid Deficiency in Development of a Model of Endogenous Renal Prostaglandin Deficiency.  Prostaglandins Leukotrienes Med. 19, 87-98 (1985).

344.     P. L. Ogburn, Jr., S. I. Turner, P. P. Williams, S. B. Johnson and R. T. Holman.  Preeclampsia and Essential Fatty Acid Patterns.  Prog. Lipid Res. 25, 417-419 (1986).

345.     Paul L. Ogburn, Jr., Preston P. Williams, Susan B. Johnson and Ralph T. Holman.  Letter to the Editor "Response to Drs. Rosing and Olund."  Am. J. Obstet. Gynecol. 153, 714 (1985).

346.     Editor, Progress in Lipid Research, Pergamon Press, Vol. 21, 336 pages (1982).

347.     Editor, Progress in Lipid Research, Pergamon Press, Vol. 22, 299 pages (1983).

348.     Editor, Progress in Lipid Research, Pergamon Press, Vol. 23, 246 pages (1985).

349.     Ralph T. Holman.  Essential Fatty Acids and Nutritional Disorders.  In "Lipids in Modern Nutrition," Eds. M. Horisberger and U. Bracco, Nestle' Nutrition, Vevey, Switzerland, and Raven Press, New York, pp. 157-171 (1987).

350.     Victor G. Soukup and Ralph T. Holman.  Fatty Acids of North American Pedicellate Trillium Seed.  Phytochemistry 26, 1015-1018 (1987).

351.     Ralph T. Holman.  Nutritional and Functional Requirements for Essential Fatty Acids.  In "Dietary Fat and Cancer," Eds. Clement Ip, D. F. Birt, A. E. Rogers and C. Mettlin, Alan R. Liss Publishers, New York, pp. 211-228 (1986).

352.     T. R. Kramer, M. Briske-Anderson, S. B. Johnson and R. T. Holman.  Influences of Dietary Polyunsaturated or Saturated Fats and of Concanavalin-A upon Proliferation of Spleen Lymphoid Cells from Rats.  Nutr. Res. 6, 1219-1227 (1986).

353.     R.T. Holman, C.E. Adams, R.A. Nelson, S.J.E. Grater, J.A. Jaskiewicz, S.B. Johnson and J.W. Erdman, Jr.  Patients with Anorexia Nervosa Demonstrate Deficiencies of Selected Essential Fatty Acids, Compensatory Changes in Non-essential Fatty Acids and Decreased Fluidity of Plasma Lipids.  J. Nutr. 125, 901-907 (1995)

 354.    R. T. Holman.  Conditions Influencing Essentiality of Polyunsaturated Acids.        In: "Proceedings of the NATO Advanced Research Workshop on  Advanced Technologies and their Nutritional Implications in the Production of Edible Fats," Held March 17-21, 1986 in Selvino, Italy, Eds. C. Galli and E. Fedeli, Plenum Press, NY and London, pp. 1-12 (1987).

355.     W. W. Christie, E. Y. Brechany, S. B. Johnson and R. T. Holman.  A Comparison of Pyrrolidide and Picolinyl Ester Derivatives for Identification of Fatty Acids in Natural Samples by Gas Chromatography-Mass Spectrometry.  Lipids 21, 657-661 (1986).

356.     H. L. Sharp, J. A. Lindahl, D. K. Freese, B. Burke, D. Johnson, S. B. Johnson and R. T. Holman.  A New Hepato-Pancreato-Renal Disorder Resembling Tyrosinemia Involving Neuropathy and Abnormal Metabolism of Polyunsaturated Acids.  J. Pediatr. Gastroenterol. Nutr. 7, 167-176 (1988).

357.     P. Alden, B. Svingen, S. Johnson, F. Konstantinides, R. T. Holman and F. B. Cerra.  Partial Correction of Exogenous Lipid of Abnormal Patterns of Polyunsaturated Fatty Acids in Plasma Phospholipids of Stressed and Septic Surgical Patients.  Surgery 100, 671-678 (1986).

358.     R. T. Holman.  Showy Lady's Slipper (grown and photographed by Holman), a 4       color 18" x 24" print (poster) of a triplet Minnesota's State flower to be       given to contributors to Hormel Institute research on orchids, 2000 copies       printed in 1985.

359.     B.A. Svingen, M.J. Murray, T.L. Yaksh and R. T. Holman.  Plasma Arachidonate and Lung Surfactant Composition in Unanesthetized Canine Endotoxin Shock.  Circulatory Shock        ?????

360.     A. Christophe, E. G. Hill and R. T. Holman.  Efficacy of Linoleic Acid Administered Rectally as Monoglyceride.  Lipids 22, 328-332 (1987).

361.     P. B. Alden, B. Svingen, C. Deutschman, S. B. Johnson, F. N. Konstantinides, R. T. Holman and F. B. Cerra.  Essential Fatty Acid Status in Isolated Closed Head Injury.  J. Trauma 27 (9), 1039-1043 (1987).

362.     R. T. Holman,  Ebbholmen.  A Centennial Edition of Our Family Chronicle.  Privately published. Libr. Congr. #TXu 246 877, pp. 450 (1986).

363.     J. W. Crofts, P. L. Ogburn, S. B. Johnson and R. T. Holman.  Polyunsaturated Fatty Acids of Serum Lipids in Myocardial Infarction.  Lipids 23, 539-545 (1988).

364.     Editor, Progress in Lipid Research, Pergamon Press, Vol. 24, 346 pages (1986).

365.     P. L. Ogburn, S. I. Turner, P. P. Williams, S. B. Johnson and R. T. Holman.  Essential Fatty Acid Patterns in Preeclampsia.  Zentalblatt Gynakal 108, 983-989 (1986).

366.     H. J. Dutton, S. B. Johnson, F. J. Pusch, R. T. Holman, M. S. F. Lie Ken Jie and F. D. Gunstone.  Composition of Mixed Octadecadienoates via Ozonolysis Chromatography and Computer Solutions of Linear Equations.  Lipids 23, 481-489 (1988).

367.     W. W. Christie, E. Y. Brechany, F. D. Gunstone, M. Lie Ken Jie and R. T. Holman. Mass Spectra of the Picolynyl Ester Derivatives of Some Non-Methylene-Interrupted Octadecadienoates.  Lipids 22, 664-666 (1987).

368.     D. M. Mock, S. B. Johnson and R. T. Holman.  Effects of Biotin Deficiency on Serum Fatty Acid Composition:  Evidence for Abnormalities in Humans.  J. Nutr. 118, 342-348 (1988).

369.     D. M. Mock, N. I. Mock, S. B. Johnson and R. T. Holman.  Effects of Biotin  Deficiency on Plasma and Tissue Fatty Acid Composition:  Evidence for Abnormalities Rats.  Pediatr. Res. 24, 396-403 (1988).

370.     A. M. Kools, J. G. Straka, H. D. Hill, D. I. Whitmer, R. T. Holman and J. R. Bloomer.  Modulation of Hepatic Ferrochelatase Activity by Dietary Manipulation of Mitochondrial Phospholipid Fatty Acyl Groups.  Hepatology 9, 557-561 (1989).

371.     J. D. Lloyd-Still, S. B. Johnson and R. T. Holman.  Essential Fatty Acid Status and Fluidity of Plasma Phospholipids in Cystic Fibrosis Infants.  Am. J. Clin. Nutr. 54, 1029-1035 (1991).  

372.     I. I. Rusoff, R. T. Holman and G. O. Burr.  Spectroscopic Data in Fats, Fatty  Acids and Their Esters.  Soap, Perfumery Cosmet. Yr. Book 1965, 53-57.

373.     R. T. Holman.  George O. Burr and the Discovery of Essential Fatty Acids.  J. Nutr. 118, 535-540 (1988).

374.     R. T. Holman.  A Brief History of "Progress in Lipid Research".  Prog. Lipid Res. 27, 1-4 (1988).

375.     S. D. Phinney, R. S. Odin, S. B. Johnson and R. T. Holman.  Reduced Arachidonate in  Serum Phospholipids and Cholesteryl Esters associated with Vegetarian Diets in Humans.  Am. J. Clin. Nutr. 51, 385-392 (1990).

376.     F. B. Cerra, P. B. Alden, F. Negro, T. Billiar, B. A. Svingen, J. Licari, S. B. Johnson and R. T. Holman.  Sepsis and Exogenous Lipid Modulation.  J. Parenter. Enterol. Nutr. 12, 63S-68S (1988).

377.     S. B. Johnson, T. R. Kramer, M. Briske-Anderson and R. T. Holman.  Fatty Acid Pattern of Tissue Phospholipids in Copper and Iron Deficiencies.  Lipids 24, 141-145 (1989).

378.     Editor, Progress in Lipid Research, Pergamon Press, Vol. 25, 693 pages (1986).

379.     Editor, Progress in Lipid Research, Pergamon Press, Vol. 26, 348 pages (1987).

380.     R. T. Holman.  Upsala Community Covenant Church.  A Swedish Pioneer Church 1888-1988.  Privately published, Libr. Congr. #TXu 304 974, pp. 143 (1987).

381.     T. R. Billiar, P. E. Bankey, B. A. Svingen, R. D. Curran, M. A. West, R. T. Holman, R. L. Simmons and F. B. Cerra.  Fatty Acid Intake and Kupffer Cell Function:  Fish Oil Alters Eicosanoid and Monokine Production to Endotoxin Stimulation.  Surgery 104, 343-349 (1988).

382.     S.D. Phinney, P.G. Davis, S.B. Johnson, and R. T. Holman.  Obesity and Weight Loss Alter Serum Polyunsaturated Lipids in Humans.  Am. J. Clin. Nutr. 53, 831-838 (1991).

383.     S.D. Phinney, S.B. Johnson, R.T. Holman, A.M. Reisenauer, and C.H. Halsted.  Chronic Ethanol Ingestion Selectively Impairs Essential Fatty Acid Desaturation in the Miniature Pig.  Submitted to Alcoholism.

384.     R.T. Holman.  James Franklyn Mead October 24, 1916 to November 30, 1987.  Lipids 24, 166 (1989).

385.     R.T. Holman, S.B. Johnson and Emre Kokmen.  Deficiencies of Polyunsaturated Fatty Acids and Replacement by Non-essential Fatty Acids in Plasma Lipids in Multiple Sclerosis.  Proc. Natl. Acad. Sci. USA 86, 4720-4724 (1989).

386.    

387.     R.G. Knodell, D.I. Whitmer, and R.T. Holman.  Influence of Hyperalimentation on Rat Hepatic Microsomal Fluidity and Function.  Gastroenterology 98, 1320-1325 (1990).

388.     E.S. Kang, S.B. Johnson, and R.T. Holman.   Fatty Acid Composition of Hepatic Triglycerides from Reye's Syndrome:  Implications for Hepatic Desaturase Abnormalities.  Clin. Chim. Acta 204, 167-178 (1991).

389.     R.T. Holman.  Highpoints in an Affair with Polyunsaturated Acids.  In "Health Effects of w3 Polyunsataturated Fatty Acids in Seafoods", World Review of Nutritionand Dietetics, Vol. 66 (A.P. Simopoulos, Series Ed.) (A.P. Simopoulos, R. R. Kifer, R. E. Martin and J. M. Barlow, Volume Eds.) Karger, Basel, pp. 4-8 (1991)

390.     S. Pullman-Mooar, M. Laposata, D. Lem, R.T. Holman, L.J. Leventhal, D. De Marco, and R.B. Zurier.  Alteration of the Cellular Fatty Acid Profile and the Production of Eicosanoids in Human Monocytes by Gamma-Linolenic Acid.  Arthritis Rheum. 33, 1526-1533 (1990).

391.     S.D. Phinney, P.G. Davis, S.B. Johnson, and R.T. Holman.  Obesity and Weight Loss Alter Serum Polyunsaturated Fatty Acid Metabolism in Humans.  Am. J. Clin. Nutr. 53, 831-838 (1991).

392.     S.D. Phinney, A.B. Tang, S.B. Johnson, and R.T. Holman.  Reduced Adipose 18:3w3 with Weight Loss by Very Low Caloric Dieting.  Lipids 25, 798-806 (1990).

393.     F.B. Cerra, S. Lehmann, N. Konstantinides, F. Konstantinides, E.P. Shronts, and R.T. Holman.  Effect of Enteral Nutrient on in vitro Tests of Immune Function in ICU Patients:  A Preliminary Report.  Nutrition 6, 84-87 (1990).

394.     R.T. Holman.  Control of Polyunsaturated Acids in Tissue Lipids.  In "Oil and Fat in Nutrition and Disease" (Ichiro Hara, Hiroyuki Shimasaki, Yoshiaki Machida, Eds.) Saiwai Shobo Company, Japan, pp. 2-42 (1990)  Translated to Japanese 1990

395.     J.S. Crockett, M. Gross, W.W. Christie, and R.T. Holman.  Collisional Activation of a Series of Homoconjugated Octadecadienoic Acids with Fast Atom Bombardment and Tandem Mass Spectrometry.  J. Am. Soc. Mass Spectrom. 1, 183-191 (1990).

396.     R.T. Holman, F. Pusch, B. Svingen, and H.J. Dutton.  Unusual Isomeric Polyunsaturated Fatty Acids in Liver Phospholipids in Rats Fed Hydrogenated Oil.  Proc. Natl. Acad. Sci. USA 88, 4830-4834 (1991).

397.     F.B. Cerra, R.T. Holman, P.E. Bankey, J.E. Mazuski, and J.J. LiCari.  w3 Polyunsaturated Fatty Acids as Modulators of Cellular Function in the Critically Ill.  Pharmacotherapy 11(1), 71-76 (1991).

398.     M.J. Murray, B.A. Svingen, R.T. Holman, and T.L. Yaksh.  The Effects of Fish Oil Diet on Pigs' Cardiopulmonary Response to Bacteremia.  J. Parent. Enteral. Nutr. 15, 152-158 (1991).

399.     R.T. Holman.  Hugh MacDonald Sinclair:  Advocate of the Essential Fatty Acids.  In "Health Effects of w3 Polyunsaturataed Fatty Acids in Seafoods", World Review of Nutrition and Dietetics, Vol. 66 (A.P. Simopoulos, Series Ed.) (A.P. Simopoulos, R.R. Kifer, R.E. Martin, and J.M. Barlow, Volume Eds) Karger, Basel, pp. XX-XXIV (Dedication) (1991).

400.     M.J. Murray, B.A. Svingen, T.L. Yaksh, and R.T. Holman.  Effects of Endotoxin on Pigs Prefed w-3 vs w-6 Fatty Acid-Enriched Diets.  Am. J. Physiol. 265, E920-E927 (1993).

401.     B.M. Myers, F.G. Prendergast, R.T. Holman, S.M. Kuntz, and N.F. La Russo.  Alterations in the Structure, Physicochemical Properties and pH of Hepatocyte Liposomes in Experimental Iron Overload.  J. Clin. Invest. 88, 1207-1215 (1991).

402.     R.T. Holman, S.B. Johnson, and P.L. Ogburn.  Deficiency of Essential Fatty Acids and Membrane Fluidity During Pregnancy and Lactation.  Proc. Natl. Acad. Sci. USA 88, 4835-4839 (1991).

403.     A.B. Christophe, and R.T. Holman.  Diet and EFA Status in Cystic Fibrosis Patients.  INFORM 3, 449-455 (1992).

404.     F.B. Cerra, R.T. Holman, P.E. Bankey, and J.E. Mazuski.  Nutritional Pharmacology:  Its Role in the Hypermetabolism-Organ Failure Syndrome.  Critical Care Medicine 18, S154-S158 (1990).

405.     P.E. Bankey, T.R. Billiar, W.Y. Yeng, A. Carlson, R.T. Holman, and F.B. Cerra.  Modulation of Kupffer cell membrane phospholipid function by n-3 polyunsaturated fatty acids.  J. Surg. Res. 46, 439-444 (1989).

406.     F.B. Cerra, S. Lehmann, N. Konstantinides, J. Dzik, J. Fish, F. Konstantinides, J.J. LiCari, and R.T. Holman.  Improvement in Immune Function in ICU Patients by Enteral Nutrition Supplemented with Arginine, RNA, and Menhaden Oil is Independent of Nitrogen Balance.  Nutrition 7, 193-199 (1991).

407.     D. Spielmann, H. Traitler, G. Crozier, M. Fleith, U. Bracco, P.A. Finot, M. Berger, and R.T. Holman.  Biochemical and Bioclinical Aspects of Blackcurrant Seed Oil w3 and w6 Balanced Oil.  In "Dietary w3 and w6 Fatty Acids (G. Galli and A. P. Simopoulos, Eds.) Plenum Publishing Corp., pp. 309-321 (1989).

408.     R.T. Holman, S.B. Johnson, D. Bibus, D.C. Spencer, and J.V. Donadio, Jr.  Essential Fatty Acid Deficiency Profiles in Idiopathic Immunoglobulin A Nephropathy.  Am. J. Kidney Dis. 23, 648-654 (1994). 

409.     R.T. Holman, and H.J. Dutton.  Essential Fatty Acid Deficient Rats Fed Hydrogenated Oil - A Response.  Lipids 27, 486 (1992).

410.     W.W. Christie, E.Y. Brechany, and R.T. Holman.  Mass Spectra of the Picolinyl Esters of Isomeric Mono- and Dienoic Fatty Acids.  Lipids 22, 224-228 (1987).

411.     T. Zhang, M.J. Murray, K. Klocke, J.M. Miles, and R.T. Holman.  The Effects of the Incubation of Long-Chain Polyunsaturated Fatty Acids on Platelet Lipids and Thromboxane Release.  Submitted to J. Lipid Res. 4/29/93.  Being revised for a different journal - per Murray's secretary 5/16/94.

412.     R.T. Holman.  A Long Scaly Tale - The Study of Essential Fatty Acid Deficiency at the University of Minnesota.  In "Essential Fatty Acids and Eicosanoids" (Andrew Sinclair and Robert Gibson, Eds.) American Oil Chemists' Society, Champaign, IL, pp. 3-17 (1993).

413.     S.D. Phinney, J.S. Stern, K.E. Burke, A.B. Tang, G. Miller, and R.T. Holman.  Human Subcutaneous Adipose Tissue Shows Site-Specific Differences in Polyunsaturated Fatty Acid Composition. Am. J. Clin. Nutr. 60; 725-729 (1994)

414.     D. Lax, R.T. Holman, S.B. Johnson, S.L. Zang, Y. Li, G.R. Noren, N.A. Staley, and S. Einzig.  Myocardial Lipid Composition in Turkeys with Dilated Cardiomyopathy.  Cardiovascular Res. 28, 407-413 (1994).

415.     B.M. Myers, F.G. Prendergast, R.T. Holman, S.M. Kuntz and N.F. LaRusso.  Alterations in Hepatocyte Lysosomes in Experimental Hepatic Copper Overload in Rats.  Gasteroenterology 105, 1814-1823 (1993).

416.     R.T. Holman.  A Brief History of PROGRESS IN LIPID RESEARCH.  In "Robert Maxwell & Pergamon Press" (E. Maxwell, Ed), Pergamon Press, New York, NY, pp.305-308 (1988).

417.     R.T. Holman, D.M. Bibus, G.H. Jeffrey, P. Smethurst and J.W. Crofts.  Abnormal Plasma Lipids of Patients with Retinitis Pigmentosa.  Lipids 29, 61-65 (1994).

418.     R.T. Holman.  Omega 3 Deficiencies in Humans.  In "Proceedings of the 55th Flax Institute of the United States" (J.F. Carta, Ed.) pp. 4-11 (1994).

419.     A.J. Sinclair, L. Johnson, K. O'Dea and R.T. Holman.  Diets Rich in Lean Beef Increase Arachidonic Acid and Long-Chain w3 Polyunsaturated Fatty Acid Levels in Plasma Phospholipids.  Lipids 29, 337-343 (1994).

420.     A.B. Christophe, W.J. Warwick and R.T. Holman.  Serum Fatty Acid Profiles in Cystic fibrosis patients and their parents.  Lipids 29, 569-575 (1994).

421.     R.T. Holman, C.E. Adams, R.A. Nelson, S.J.E. Grater, J.A. Jaskiewicz, S.B. Johnson and J.W. Erdman, Jr.  Patients with Anorexia Nervosa Demonstrate Deficiencies of Selected Essential Fatty Acids, Compensatory Changes in Nonessential Fatty Acids and Decreased Fluidity of Plasma Lipids.  J. Nutr. 125, 901-907 (1995).

422.     S.D. Phinney, J.S. Stern, K.E. Burke, A.B. Tang, G. Miller and R.T. Holman.  Human Subcutaneous Adipose Tissue Shows Site-Specific Differences in Fatty Acid Composition.  Am. J. Nutr. 60, 725-729 (1994).

423.     P.S. Tietz, R.T. Holman, L.J. Miller and N.F. LaRusso.  Isolation and Characterization of Rat Cholangiocyte Vesicles Enriched in Apical or Basolateral Plasma Membrane Domains.  Biochemistry 34, 15436-15443 (1995).

424.     T. Zhang, M.J. Murray, K. Klocke, J.M. Miles and R.T. Holman.  The Effects of the Incubation of Long-Chain Polyunsaturated Fatty Acids on Platelet Lipids and Thromboxane Release.  Submitted to Prost. Leuk. Ess. Fatty Acids. 12/27/95.

425.     R.T. Holman.  How I Became a Lipid Chemist 50 Years Ago. INFORM 7: 402-408 (1996)

426.     R.T. Holman.  Fifty Years Ago - How I Got My Start In Lipids, and Where It Led Me. FASEB J. 10, 931-934 (1996)

427.     R. T. Holman.  Omega 3 and Omega 6 Essential Fatty Acid Status in Human Health and Disease.  in “Fatty Acids and Behavior”, eds S. Yehuda and D. Mostofsky.  Humana Press, Totowa, N.J.  pp 000-000  Nov. 1996

428.  R. T. Holman.   Deficiencies of Essential Omega 3 Fatty Acids in Humans Are Not Rare.  Proc. of the 56th Flax Institute of the United States ,  Fargo, N.D. pp. 1-8 (1996)

429.  J. Lloyd-Still, D. Bibus,  O. Powers, S. Johnson and R.T. Holman.  Essential Fatty  Acid Deficiency and Predisposition to Lung Disease in Cystic Fibrosis.  subm. Acta Paediatrica  1996

430.  Ralph T. Holman, S.B. Johnson, D. M. Bibus, T.C. Okeahiaalem and Peter O. Egwim.
High Omega 3 EFA Status in Nigerians and Low Status in Minnesotans.  Submitted to
W. W. W. J. Biol Sept. 1996

431.  Robert  B. Zurier, Douglas M. Bibus and Ralph T. Holman.  Deficiencies of Polyunsaturated Fatty Acids and Replacement by Nonessential Fatty Acids in Plasma Lipids of Rheumatoid Arthritis Patients.  Submittet to Lipids  18oct96

432.  Ralph T. Holman, N.L.Parinandi, Eva Deli,  Douglas Bibus, R. Kaleysa Raj and T. Ramasarma.  High w3 Nutritive Status Indicated by Essential Fatty Acid Profiles in Keralites of India.  Manuscript in preparation.



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