No. 3 on the “fab 5” list!
In celebration of the 50th volume of the AOCS journal Lipids, we are featuring one paper each month from a list of five pivotal original papers representing the broad areas of research from the first 49 volumes of the journal. All five articles are available free of charge at http://tinyurl.com/Lipids-Fab-5
This month’s paper—No. 3 on the “Fab 5” list—was written by William A. Pryor, J.P. Stanley, and E. Blair at Louisiana State University in Baton Rouge. It appeared in 1976, has been cited more than 500 times, and is titled “Autoxidation of polyunsaturated fatty acids: II. A suggested mechanism for the formation of TBA-reactive materials from prostaglandin-like endoperoxides.”
“This paper helped form the foundation in the literature that polyunsaturated fatty acids (PUFA) are subject to free radical-initiated autoxidation and form endoperoxides,” notes Lipids Editor-in-Chief Eric J. Murphy, which are now recognized as an important part of the pathophysiology of numerous human diseases, including atherosclerosis and cancer. By using several mass spectrometric techniques, the researchers determined that oxidation of methyl linolenate results in endoperoxide formation and that these products go on to form malonaldehyde. By extension, other PUFA would be subject to autoxidation to form endoperoxides and are the source of the TBA-reactive [thiobarbituric acid] materials in autoxidation systems, now known to contain mainly malondialdehyde formed via PUFA autoxidation.
Find Out More
In celebration of the 50th volume of the AOCS journal Lipids, we are featuring one paper each month from a list of five pivotal original papers representing the broad areas of research from the first 49 volumes of the journal. All five articles are available free of charge at http://tinyurl.com/Lipids-Fab-5
This month’s paper—No. 3 on the “Fab 5” list—was written by William A. Pryor, J.P. Stanley, and E. Blair at Louisiana State University in Baton Rouge. It appeared in 1976, has been cited more than 500 times, and is titled “Autoxidation of polyunsaturated fatty acids: II. A suggested mechanism for the formation of TBA-reactive materials from prostaglandin-like endoperoxides.”
“This paper helped form the foundation in the literature that polyunsaturated fatty acids (PUFA) are subject to free radical-initiated autoxidation and form endoperoxides,” notes Lipids Editor-in-Chief Eric J. Murphy, which are now recognized as an important part of the pathophysiology of numerous human diseases, including atherosclerosis and cancer. By using several mass spectrometric techniques, the researchers determined that oxidation of methyl linolenate results in endoperoxide formation and that these products go on to form malonaldehyde. By extension, other PUFA would be subject to autoxidation to form endoperoxides and are the source of the TBA-reactive [thiobarbituric acid] materials in autoxidation systems, now known to contain mainly malondialdehyde formed via PUFA autoxidation.
Find Out More
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