Monday, January 19, 2015

FREE! Lipids paper of the month - 13-Oxo-9(Z),11(E),15(Z)-octadecatrienoic Acid Activates Peroxisome Proliferator-Activated Receptor γ in Adipocytes

January’s paper of the month is from Lipids and was reported by researchers from the Kawada Group at Kyoto University in Japan. The study shows for the first time that 13-oxo-OTA, a derivative of linolenic acid that is found in a number of fruits, activates the PPAR gamma system in 3T3-L1 adipocytes, thereby resulting in adipocyte differentiation and adipogenesis. Further, 13-oxo-OTA stimulates expression of PPAR gamma-regulated genes, increasing adiponectin secretion from adipocytes as well as glucose uptake by these cells.
“The researchers have provided additional insight into the complex role of a naturally occurring dietary PPAR gamma agonist in the regulation of the adipocyte functions that are considered to be anti-type 2 diabetic,” noted Editor-in-Chief Eric J. Murphy. “This could offer a novel dietary approach in modulating the long-term impact of diabetes.” 
The article will be available for free download through March 19.

Download the article.

13-Oxo-9(Z),11(E),15(Z)-octadecatrienoic Acid Activates Peroxisome Proliferator-Activated Receptor γ in Adipocytes
Haruya Takahashi, Hideyuki Hara, Tsuyoshi Goto, Kosuke Kamakari, Nomura Wataru, Shinsuke Mohri, Nobuyuki Takahashi, Hideyuki Suzuki, Daisuke Shibata, Teruo Kawada.
Lipids. January 2015, Volume 50, Issue 1, pp 3-12.


Peroxisome proliferator-activated receptor (PPAR)γ is expressed in adipose tissue and plays a key role in the regulation of adipogenesis. PPARγ activators are known to have potent antihyperglycemic activity and are used to treat insulin resistance associated with diabetes. Therefore, many natural and synthetic agonists of PPARγ are used in the treatment of glucose disorders. In the present study, we found that 13-oxo-9(Z),11(E),15(Z)-octadecatrienoic acid (13-oxo-OTA), a linolenic acid derivative, is present in the extract of tomato (Solanum lycopersicum), Mandarin orange (Citrus reticulata), and bitter gourd (Momordica charantia). We also found that 13-oxo-OTA activated PPARγ and induced the mRNA expression of PPARγ target genes in adipocytes, thereby promoting differentiation. Furthermore, 13-oxo-OTA induced secretion of adiponectin and stimulated glucose uptake in adipocytes. To our knowledge, this is the first study to report that 13-oxo-OTA induces adipogenesis through PPARγ activation and to present 13-oxo-OTA as a valuable food-derived compound that may be applied in the management of glucose metabolism disorders.

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