This topical collection in Lipids from the 2015 Northern Great Plains Lipid Conference (NGPLC) is featured on a Springer Chemistry Special Issues site. All articles are now available for a free download until September 10, 2016. Some of the papers are full research articles, while others are timely, topical reviews focused on lipid biochemistry and metabolism. Lipids plans to publish papers from the 2016 NGPLC in mid-2017. Many AOCS members and meeting presenters have contributed to the new conference, as explained in this editorial.